Otu deubiquitinase 5

OTUD5
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3PFY, 3TMO, 3TMP
Identifiers
Aliases	OTUD5, DUBA, OTU deubiquitinase 5
External IDs	HomoloGene: 136483 GeneCards: OTUD5
Gene location (Human)
Chr.	X chromosome (human)[1]
End	48,958,386 bp[1]
Gene ontology
Molecular function	• thiol-dependent ubiquitinyl hydrolase activity; • peptidase activity; • cysteine-type peptidase activity; • hydrolase activity; • thiol-dependent ubiquitin-specific protease activity; • Lys63-specific deubiquitinase activity; • ubiquitinyl hydrolase activity; • Lys48-specific deubiquitinase activity;
Cellular component	• cytosol;
Biological process	• negative regulation of type I interferon production; • response to lipopolysaccharide; • protein K63-linked deubiquitination; • protein K48-linked deubiquitination; • proteolysis; • protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	55593
	n/a
	ENSG00000068308
	n/a
	Q96G74
	n/a
	NM_001136157; NM_001136158; NM_001136159; NM_017602
	n/a
	NP_001129629; NP_001129630; NP_001129631; NP_060072
	n/a
	Wikidata
View/Edit Human

OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene. ^[3]

Function

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.

Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). "DUBA: a deubiquitinase that regulates type I interferon production". Science. 318 (5856): 1628–32. doi:10.1126/science.1145918. PMID 17991829.
Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). "Phosphorylation-dependent activity of the deubiquitinase DUBA". Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969.
Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). "OTUD5 regulates p53 stability by deubiquitinating p53". PLoS ONE. 8 (10): e77682. doi:10.1371/journal.pone.0077682. PMC 3797110. PMID 24143256.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000068308 - Ensembl, May 2017

[2] "Human PubMed Reference:".

[entrez-3] "Entrez Gene: OTU deubiquitinase 5". Retrieved 2017-03-25.

Otu deubiquitinase 5

Function

References

Further reading