Olke C. Uhlenbeck

O. C. Uhlenbeck
Residence United States
Citizenship American
Alma mater University of Michigan
Harvard University
Known for RNA synthesis from synthetic templates, RNA-protein interactions, RNA Biochemistry
Scientific career
Fields Biochemistry
Biophysics
Institutions University of Illinois
University of Colorado
Northwestern University
Doctoral advisor Paul Doty
Notes
His father was the famous Physicist George Eugene Uhlenbeck.

Olke C. Uhlenbeck is a biochemist presently at Northwestern University.[1] He was elected to the United States National Academy of Sciences in 1993 [2] and has published over 200 peer-reviewed articles.[3] His research group has led to many breakthroughs in RNA biochemistry, most notably the enzymatic synthesis of RNAs from synthetic DNA templates using T7 RNA polymerase.[4] Olke was a founding member of the RNA society.[5]

Early Contributions

As a graduate student in Paul Doty's lab, Olke showed that the anticodon of tRNA was accessible to hybridization to oligonucleotides.[6] Later, as a Miller Research Fellow in Ignacio Tinoco, Jr.'s lab he helped define an original model for RNA secondary structure prediction.[7]

Contributions from the Uhlenbeck Lab

Olke is a longstanding contributor to RNA biochemistry. His group has shown many important findings as well as developed important tools for RNA biochemists. Notable contributions include:

  • Walker, G. C.; Uhlenbeck, OC; Bedows, E; Gumport, RI (1975). "T4-Induced RNA Ligase Joins Single-Stranded Oligoribonucleotides". Proceedings of the National Academy of Sciences. 72 (1): 122–6. Bibcode:1975PNAS...72..122W. doi:10.1073/pnas.72.1.122. PMC 432253. PMID 1090929.
  • England, Thomas E.; Uhlenbeck, Olke C. (1978). "3′-Terminal labelling of RNA with T4 RNA ligase". Nature. 275 (5680): 560–1. Bibcode:1978Natur.275..560E. doi:10.1038/275560a0. PMID 692735.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  • Hertel, Klemens J.; Herschlag, Daniel; Uhlenbeck, Olke C. (1994). "A Kinetic and Thermodynamic Framework for the Hammerhead Ribozyme Reaction". Biochemistry. 33 (11): 3374–85. doi:10.1021/bi00177a031. PMID 8136375.
  • Johansson, H. E. (1998). "A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein". Proceedings of the National Academy of Sciences. 95: 9244–9. Bibcode:1998PNAS...95.9244J. doi:10.1073/pnas.95.16.9244. PMC 21323.
  • Sampson, J. R. (1988). "Biochemical and Physical Characterization of an Unmodified Yeast Phenylalanine Transfer RNA Transcribed in vitro". Proceedings of the National Academy of Sciences. 85: 1033–7. Bibcode:1988PNAS...85.1033S. doi:10.1073/pnas.85.4.1033. JSTOR 30928. PMC 279695.
  • Sampson, JR; Direnzo, A.; Behlen, L.; Uhlenbeck, O. (1989). "Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase". Science. 243 (4896): 1363–6. Bibcode:1989Sci...243.1363S. doi:10.1126/science.2646717. PMID 2646717.
  • Lariviere, F. J.; Wolfson, AD; Uhlenbeck, OC (2001). "Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation". Science. 294 (5540): 165–8. Bibcode:2001Sci...294..165L. doi:10.1126/science.1064242. PMID 11588263.

See also

List of RNA biologists

References

  1. ↑ "Northwestern University Department of Molecular Biosciences The Uhlenbeck Lab Home". Biochem.northwestern.edu. Retrieved 2011-03-02.
  2. ↑ "National Academy of Sciences:". Nasonline.org. Retrieved 2011-03-02.
  3. ↑ ""Uhlenbeck OC"[Author] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2011-10-03. Retrieved 2011-12-02.
  4. ↑ Milligan, John F.; Groebe, Duncan R.; Witherell, Gary W.; Uhlenbeck, Olke C. (1987). "Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates". Nucleic Acids Research. 15 (21): 8783–98. doi:10.1093/nar/15.21.8783. PMC 306405. PMID 3684574.
  5. ↑ "An Imperfect Account of the Founding of the RNA Society". The RNA society.
  6. ↑ Uhlenbeck, Olke C.; Baller, Julie; Doty, Paul (1970). "Complementary Oligonucleotide Binding to the Anticodon Loop of fMet-transfer RNA". Nature. 225 (5232): 508–10. Bibcode:1970Natur.225..508U. doi:10.1038/225508a0. PMID 5411856.
  7. ↑ Tinoco, Ignacio; Uhlenbeck, Olke C.; Levine, Mark D. (1971). "Estimation of Secondary Structure in Ribonucleic Acids". Nature. 230 (5293): 362–7. Bibcode:1971Natur.230..362T. doi:10.1038/230362a0. PMID 4927725.
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