Octreotate

Octreotate
Identifiers
3D model (JSmol)	Interactive image;
	InChI InChI=1S/C49H64N10O11S2/c1-27(60)40-48(68)57-39(47(67)59-41(28(2)61)49(69)70)26-72-71-25-38(56-42(62)33(51)21-29-13-5-3-6-14-29)46(66)54-36(22-30-15-7-4-8-16-30)44(64)55-37(23-31-24-52-34-18-10-9-17-32(31)34)45(65)53-35(43(63)58-40)19-11-12-20-50/h3-10,13-18,24,27-28,33,35-41,52,60-61H,11-12,19-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,66)(H,55,64)(H,56,62)(H,57,68)(H,58,63)(H,59,67)(H,69,70)/t27-,28-,33-,35+,36+,37-,38+,39+,40+,41+/m1/s1 Key: KEKAEHDXIJNAIJ-WNIOSIORSA-N;
	SMILES c3[nH]c1ccccc1c3CC2NC(=O)C(NC(=O)C(NC(=O)C(N)Cc5ccccc5)CSSCC(C(=O)NC(C(O)=O)C(C)O)NC(=O)C(C(O)C)NC(=O)C(CCCCN)NC2=O)Cc4ccccc4;
Properties
Chemical formula	C49H64N10O11S2
Molar mass	1,033.23 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Octreotate or octreotide acid is a somatostatin analogue that is closely related to octreotide. Its amino acid sequence is

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OH

while octreotide has the terminal threonine reduced to the corresponding amino alcohol.

References

Laznicek, M.; Laznickova, A.; Mäcke, H. R.; Eisenwiener, K.; Reubi, J. C.; Wenger, S. (2002). "Octreotide and Octreotate Derivatives Radiolabeled with Yttrium: Pharmacokinetics in Rats". Cancer Biotherapy & Radiopharmaceuticals. 17 (5): 527–533. doi:10.1089/108497802760804754. PMID 12470422.

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GH/IGF-1 axis signaling modulators
GH (somatotropin)	Agonists: Albusomatropin Bovine somatotropin Efpegsomatropin Eftansomatropin alfa Growth hormone Human placental lactogen Placental growth hormone (growth hormone variant) Somagrebove Somapacitan Somatosalm Somatotropin Somatropin pegol Somatrem Sometribove Somatrogon (MOD-4023; hGH-CTP) Somavaratan Somavubove Somidobove Antagonists: G120K-hGH Pegvisomant Antisense oligonucleotides: Atesidorsen Binding proteins: GHBP
GHIH (somatostatin)	Agonists: BIM-23052 CH-275 Cortistatin-14 Depreotide Edotreotide Ilatreotide L-803,087 L-817,818 Lanreotide NNC 26-9100 Octreotate Octreotide Pasireotide Pentetreotide RC-160 Seglitide Somatostatin (GHIH) Somatostatin (1-28) SRIF-14 SRIF-28 TT-232 Vapreotide Veldoreotide Antagonists: BIM-23056 Cyclosomatostatin CYN-154806 Satoreotide
GHRH (somatocrinin)	Agonists: Peptide: ALRN-5281 CJC-1295 Dumorelin GHRH Modified GRF (1-29) Rismorelin Sermorelin Somatorelin Tesamorelin Antagonists: MZ-5-156
GHS (ghrelin)	Agonists: Peptide: Alexamorelin Cortistatin-14 EP-51216 Examorelin (hexarelin) Ghrelin GHRP-1 GHRP-3 GHRP-4 GHRP-5 GHRP-6 Ipamorelin Lenomorelin Livoletide LY-444711 Pralmorelin (GHRP-2) Relamorelin Tabimorelin Ulimorelin; Non-peptide: Adenosine Anamorelin Capromorelin CP-464709 Ibutamoren (MK-677) L-692,585 Macimorelin SM-130686; Unsorted: LY-426410 LY-444711 Antagonists: A-778193 Cortistatin-8 (D-Lys³)-GHRP-6 JMV2959 YIL-781
IGF-1 (somatomedin)	See here instead.
See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators

Identifiers

3D model (JSmol)	Interactive image
InChI InChI=1S/C49H64N10O11S2/c1-27(60)40-48(68)57-39(47(67)59-41(28(2)61)49(69)70)26-72-71-25-38(56-42(62)33(51)21-29-13-5-3-6-14-29)46(66)54-36(22-30-15-7-4-8-16-30)44(64)55-37(23-31-24-52-34-18-10-9-17-32(31)34)45(65)53-35(43(63)58-40)19-11-12-20-50/h3-10,13-18,24,27-28,33,35-41,52,60-61H,11-12,19-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,66)(H,55,64)(H,56,62)(H,57,68)(H,58,63)(H,59,67)(H,69,70)/t27-,28-,33-,35+,36+,37-,38+,39+,40+,41+/m1/s1 Key: KEKAEHDXIJNAIJ-WNIOSIORSA-N
SMILES c3[nH]c1ccccc1c3CC2NC(=O)C(NC(=O)C(NC(=O)C(N)Cc5ccccc5)CSSCC(C(=O)NC(C(O)=O)C(C)O)NC(=O)C(C(O)C)NC(=O)C(CCCCN)NC2=O)Cc4ccccc4
Properties
Chemical formula	C₄₉H₆₄N₁₀O₁₁S₂
Molar mass	1,033.23 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Octreotate

See also

References