OXA1L

OXA1L
Identifiers
Aliases	OXA1L, OXA1, mitochondrial inner membrane protein
External IDs	MGI: 1916339 HomoloGene: 31281 GeneCards: OXA1L
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	22,773,041 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	54,369,673 bp[2]
Gene ontology
Molecular function	• mitochondrial ribosome binding; • protein binding; • protein homodimerization activity; • membrane insertase activity;
Cellular component	• integral component of membrane; • mitochondrial inner membrane; • integral component of mitochondrial membrane; • mitochondrial membrane; • mitochondrion; • membrane; • mitochondrial respiratory chain; • macromolecular complex; • mitochondrial matrix;
Biological process	• negative regulation of ATPase activity; • aerobic respiration; • mitochondrial proton-transporting ATP synthase complex assembly; • oxidation-reduction process; • protein tetramerization; • negative regulation of oxidoreductase activity; • mitochondrial respiratory chain complex I assembly; • macromolecular complex assembly; • protein transport; • mitochondrial translational elongation; • mitochondrial translational termination;
	Sources:Amigo / QuickGO
Orthologs
	5018
	69089
	ENSG00000155463
	ENSMUSG00000000959
	Q15070
	Q8BGA9
	NM_005015
	NM_026936
	NP_005006
	NP_081212
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2.^[5] The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.^[6]^[7]

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000155463 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000959 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID 8586451.
↑ Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi:10.1074/jbc.M110.148262. PMC 2934699. PMID 20601428.
↑ Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi:10.1074/jbc.M110.163808. PMC 2966113. PMID 20739282.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155463 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000959 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8586451-5] Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID 8586451.

[Haque_2010a-6] Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi:10.1074/jbc.M110.148262. PMC 2934699. PMID 20601428.

[Haque_2010b-7] Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi:10.1074/jbc.M110.163808. PMC 2966113. PMID 20739282.