OLA1

OLA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOLA1, DOC45, GBP45, GTBP9, GTPBP9, PTD004, Obg-like ATPase 1, Obg like ATPase 1
External IDsMGI: 1914309 HomoloGene: 5361 GeneCards: OLA1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q31.1Start174,072,447 bp[1]
End174,248,698 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

29789

67059

Ensembl

ENSG00000138430

ENSMUSG00000027108

UniProt

Q9NTK5

Q9CZ30

RefSeq (mRNA)

NM_013341
NM_001011708
NM_001328688

NM_025942
NM_030091

RefSeq (protein)

NP_001011708
NP_001315617
NP_037473

NP_080218
NP_084367

Location (UCSC)Chr 2: 174.07 – 174.25 MbChr 2: 73.09 – 73.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Obg-like ATPase 1 is an enzyme that in humans is encoded by the OLA1 gene.[5][6] Ola1 belongs to the protein family of Obg-like GTPases but defines an exceptional example of a protein that has evolved altered nucleotide specificity and binds adenosine triphosphate (ATP) with higher affinity than guanosine triphosphate (GTP).[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138430 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027108 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Koller-Eichhorn R, Marquardt T, Gail R, Wittinghofer A, Kostrewa D, Kutay U, Kambach C (Jul 2007). "Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins". J Biol Chem. 282 (27): 19928–37. doi:10.1074/jbc.M700541200. PMID 17430889.
  6. ↑ "Entrez Gene: GTPBP9 GTP-binding protein 9 (putative)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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