Nitarsone

Nitarsone
Names
IUPAC name
(4-Nitrophenyl)arsonic acid
Other names
(p-Nitrophenyl)arsonic acid; 4-Nitrobenzenearsonic acid
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.002.451
Properties
C6H6AsNO5
Molar mass 247.04 g·mol−1
Melting point 298–300 °C (568–572 °F; 571–573 K) (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease).[1] It is marketed as Histostat by Zoetis, a publicly traded subsidiary of Pfizer.[2]

Nitarsone was one of four arsenical animal drugs approved by the U.S. Food and Drug Administration for use in poultry, along with roxarsone, arsanilic acid, and carbarsone.[3] Following the 2011 suspension of roxarsone sales in the United States, however, it is believed to be the only arsenical animal drug currently marketed in the U.S.[3][4] In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic acid, and carbarsone approvals, leaving only nitarsone approvals in place.[5] When the withdrawals occurred, nitarsone was only arsenical approved for use in food animals in the U.S. In 2015 FDA withdrew the approval of using nitarsone in animal feeds. The ban came into effect at the end of 2015.[6]

References

  1. ↑ U.S. Food and Drug Administration. "Animal Drugs @ FDA".
  2. ↑ Zoetis. "Histostat: Type A Medicated Feed Article".
  3. 1 2 U.S. Food and Drug Administration (June 8, 2011). "Questions and Answers Regarding 3-Nitro (Roxarsone)".
  4. ↑ Sabrina Tavernise (May 11, 2013). "Study Finds an Increase in Arsenic Levels in Chicken". New York Times.
  5. ↑ U.S. Food and Drug Administration (September 20, 2011). "FDA Response to Citizen Petition on Arsenic-based Animal Drugs".
  6. ↑ U.S. Food and Drug Administration (April 1, 2015). "FDA Announces Pending Withdrawal of Approval of Nitarsone".
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.