Nektar Therapeutics

Nektar Therapeutics
Public
Traded as
Industry Biopharmaceuticals
Founded 1990
Headquarters San Francisco, California
Products Exubera, Movantik[1]
Revenue $148.92 million (As of 2013)[2]
Website nektar.com

Nektar Therapeutics (Nektar) is an American biopharmaceutical company. The company was founded in 1990 and is based in San Francisco, California.[3] The company develops new drug candidates by applying its proprietary PEGylation and advanced polymer conjugate technologies to modify chemical structure of substances.[4] It is a technology supplier to a number of pharmaceutical companies including Affymax, Amgen, Merck, Pfizer and UCB Pharma, etc.[3] The company developed the world's first inhalable non-injectable insulin, Exubera, which was awarded as the bronze award by Wall Street Journal for its technological breakthrough.

Background

The company is engaged in developing a proprietary pipeline of drug candidates for several therapeutic areas including oncology, pain, anti-infectives, anti-viral and immunology.[3] The company's research and development involve in small molecule and biologic drug candidates. Its drug candidate base consists of naloxegol (Movantik), a Phase III oral opioid antagonist, etirinotecan pegol, a topoisomerase inhibitor under Phase III clinical study as of 2012, NKTR 061, NKTR-181, NKTR-214, etc.[5]

In 2013, the company was assigned a patent which was developed by the company and other four co-inventors.[6] The products of the company is served as a supplement to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability and other areas of drugs for the patients worldwide.[7] As of March 2014, the company had an market capitalization of $1.7 billion with an enterprise value of $1.67 billion.[2]

Pipeline

Etirinotecan pegol was in the phase III BEACON trial, and is in the I-SPY2 adaptive clinical trial for breast cancer.[8]

NKTR-214 is a CD122-biased immune-stimulatory cytokine[9] Phase I results announced in Nov 2016.[10] It is now in a phase 2 trial in combination with nivolumab for various advanced cancers.[11]

References

  1. ↑ Nektar Therapeutics Profile|https://finance.yahoo.com/q/pr?s=NKTR+Profile
  2. 1 2 "NKTR Key Statistics | Nektar Therapeutics Inc Stock - Yahoo! Finance". Finance.yahoo.com. Retrieved 2014-03-16.
  3. 1 2 3 "BDR: Summary for Nektar Therapeutics, Inc.- Yahoo! Finance". Finance.yahoo.com. Retrieved 2014-03-17.
  4. ↑ "Nextar Therapeutics Inc. brief introduction NASDAQ". Nasdaq.com. Retrieved 2014-03-16.
  5. ↑ "NKTR reuter.com". Reuters.com. Retrieved 2014-03-16.
  6. ↑ "Nektar Therapeutics : U.S. Patents Awarded to Inventors in Alabama (Feb. 8)". 4-traders.com. 2014-02-08. Retrieved 2014-03-16.
  7. ↑ "Nextar Marketwatch Quote Summary". Marketwatch.com. Retrieved 2014-03-16.
  8. ↑ Novel Agents are Targeting Drivers of TNBC - Several drug candidates in I-SPY2 have 'graduated' to later-phase studies. 2016
  9. ↑ "Nektar and MD Anderson Cancer Center Announce Phase 1/2 Clinical Research Collaboration for NKTR-214, a CD122-Biased Immuno-Stimulatory Cytokine". Nektar Therapeutics. June 2, 2015. Retrieved 25 June 2015.
  10. ↑ Immunotherapy, NKTR-214, Shows Activity Against Solid Tumors in Clinical Trial
  11. ↑ NKTR-214/Nivolumab Combination Shows Promise in Early Study Nov 2017

Official website

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