Natriuretic peptide precursor C

NPPC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNPPC, CNP, CNP2, Natriuretic peptide precursor C, natriuretic peptide C
External IDsMGI: 97369 HomoloGene: 7867 GeneCards: NPPC
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q37.1Start231,921,820 bp[1]
End231,926,403 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4880

18159

Ensembl

ENSG00000163273

ENSMUSG00000026241

UniProt

P23582

Q61839

RefSeq (mRNA)

NM_024409

NM_010933

RefSeq (protein)

NP_077720

NP_035063

Location (UCSC)Chr 2: 231.92 – 231.93 MbChr 1: 86.67 – 86.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[5][6][7] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[5] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[8]

Structure of C-type natriuretic peptide (human)

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: NPPC natriuretic peptide precursor C".
  6. ↑ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  7. ↑ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  8. ↑ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.

Further reading

  • Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.
  • Suga S, Nakao K, Hosoda K, et al. (1992). "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide". Endocrinology. 130 (1): 229–39. doi:10.1210/en.130.1.229. PMID 1309330.
  • Ogawa Y, Nakao K, Nakagawa O, et al. (1992). "Human C-type natriuretic peptide. Characterization of the gene and peptide". Hypertension. 19 (6 Pt 2): 809–13. doi:10.1161/01.hyp.19.6.809. PMID 1339402.
  • Ishizaka Y, Kangawa K, Minamino N, et al. (1993). "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1". Biochem. Biophys. Res. Commun. 189 (2): 697–704. doi:10.1016/0006-291X(92)92257-X. PMID 1472040.
  • Komatsu Y, Nakao K, Suga S, et al. (1991). "C-type natriuretic peptide (CNP) in rats and humans". Endocrinology. 129 (2): 1104–6. doi:10.1210/endo-129-2-1104. PMID 1855454.
  • Tawaragi Y, Fuchimura K, Tanaka S, et al. (1991). "Gene and precursor structures of human C-type natriuretic peptide". Biochem. Biophys. Res. Commun. 175 (2): 645–51. doi:10.1016/0006-291X(91)91614-I. PMID 2018508.
  • Ogawa Y, Itoh H, Yoshitake Y, et al. (1995). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  • Kaneko T, Shirakami G, Nakao K, et al. (1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  • Wei CM, Heublein DM, Perrella MA, et al. (1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. doi:10.1161/01.cir.88.3.1004. PMID 8353861.
  • Igaki T, Itoh H, Suga S, et al. (1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. doi:10.2337/diab.45.3.s62. PMID 8674895.
  • Igaki T, Itoh H, Suga S, et al. (1996). "C-type natriuretic peptide in chronic renal failure and its action in humans". Kidney Int. Suppl. 55: S144–7. PMID 8743538.
  • Vollmar AM, Paumgartner G, Gerbes AL (1997). "Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver". Gut. 40 (1): 145–50. doi:10.1136/gut.40.1.145. PMC 1027025. PMID 9155593.
  • Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y (1997). "Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11". Biochem. Mol. Med. 61 (1): 47–51. doi:10.1006/bmme.1997.2584. PMID 9232196.
  • He Xl; Chow Dc; Martick MM; Garcia KC (2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone". Science. 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490.
  • Cataliotti A, Giordano M, De Pascale E, et al. (2002). "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". Am. J. Physiol. Renal Physiol. 283 (3): F464–72. doi:10.1152/ajprenal.00372.2001. PMID 12167597.
  • Evans JJ, Youssef AH, Yandle TG, et al. (2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells". J. Endocrinol. 175 (1): 225–32. doi:10.1677/joe.0.1750225. PMID 12379507.
  • Ono K, Mannami T, Baba S, et al. (2003). "A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension". Hypertens. Res. 25 (5): 727–30. doi:10.1291/hypres.25.727. PMID 12452325.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hirsch JR, Skutta N, Schlatter E (2003). "Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B". Am. J. Physiol. Renal Physiol. 285 (2): F370–4. doi:10.1152/ajprenal.00049.2003. PMID 12709393.
  • Wu C, Wu F, Pan J, et al. (2003). "Furin-mediated processing of Pro-C-type natriuretic peptide". J. Biol. Chem. 278 (28): 25847–52. doi:10.1074/jbc.M301223200. PMID 12736257.


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