NUDT9

NUDT9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q33, 1QVJ
Identifiers
Aliases	NUDT9, NUDT10, nudix hydrolase 9
External IDs	MGI: 1921417 HomoloGene: 11435 GeneCards: NUDT9
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	87,459,454 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	104,065,379 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• hydrolase activity; • ADP-ribose diphosphatase activity; • ADP-sugar diphosphatase activity; • adenosine-diphosphatase activity;
Cellular component	• mitochondrial matrix; • intracellular; • extracellular exosome; • mitochondrion; • cell junction; • nuclear membrane;
Biological process	• nucleobase-containing small molecule catabolic process; • IDP catabolic process; • ADP catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	53343
	74167
	ENSG00000170502
	ENSMUSG00000029310
	Q9BW91
	Q8BVU5
	NM_001248011; NM_024047; NM_198038
	NM_028794
	NP_001234940; NP_076952; NP_932155
	NP_083070
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170502 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029310 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.
↑ Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.
↑ "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

Lin S, Gasmi L, Xie Y, et al. (2002). "Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose)". Biochim. Biophys. Acta. 1594 (1): 127–35. doi:10.1016/S0167-4838(01)00296-5. PMID 11825615.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang HT, Yan ZQ, Hu XB, et al. (2004). "Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 35 (8): 747–51. PMID 12897971.
Shen BW, Perraud AL, Scharenberg A, Stoddard BL (2003). "The crystal structure and mutational analysis of human NUDT9". J. Mol. Biol. 332 (2): 385–98. doi:10.1016/S0022-2836(03)00954-9. PMID 12948489.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Carloto A, Costas MJ, Cameselle JC, et al. (2006). "The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2". Biochim. Biophys. Acta. 1760 (10): 1545–51. doi:10.1016/j.bbagen.2006.06.003. PMID 16860484.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170502 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029310 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11385575-5] Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM (May 2001). "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology". Nature. 411 (6837): 595–9. doi:10.1038/35079100. PMID 11385575.

[pmid12427752-6] Perraud AL, Shen B, Dunn CA, Rippe K, Smith MK, Bessman MJ, Stoddard BL, Scharenberg AM (Jan 2003). "NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase". J Biol Chem. 278 (3): 1794–801. doi:10.1074/jbc.M205601200. PMID 12427752.

[entrez-7] "Entrez Gene: NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9".

NUDT9

References

Further reading