NUDCD3

NUDCD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDCD3, NudCL, NudC domain containing 3
External IDsMGI: 2144158 HomoloGene: 9097 GeneCards: NUDCD3
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p13Start44,379,121 bp[1]
End44,490,880 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23386

209586

Ensembl

ENSG00000015676

ENSMUSG00000053838

UniProt

Q8IVD9

Q8R1N4

RefSeq (mRNA)

NM_015332

NM_173748
NM_001363446

RefSeq (protein)

NP_056147

NP_776109
NP_001350375

Location (UCSC)Chr 7: 44.38 – 44.49 MbChr 11: 6.11 – 6.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NudC domain-containing protein 3 is a protein that in humans is encoded by the NUDCD3 gene.[5]

Function

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000015676 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053838 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: NUDCD3 NudC domain containing 3".

Further reading

  • "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Zhou T, Zimmerman W, Liu X, Erikson RL (2006). "A mammalian NudC-like protein essential for dynein stability and cell viability". Proc. Natl. Acad. Sci. U.S.A. 103 (24): 9039–44. doi:10.1073/pnas.0602916103. PMC 1482562. PMID 16754861.


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