NPTXR

NPTXR
Identifiers
AliasesNPTXR, NPR, neuronal pentraxin receptor
External IDsMGI: 1920590 HomoloGene: 8620 GeneCards: NPTXR
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.1Start38,818,452 bp[1]
End38,843,982 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23467

73340

Ensembl

ENSG00000221890

ENSMUSG00000022421

UniProt

O95502

Q99J85

RefSeq (mRNA)

NM_058178
NM_014293

NM_030689

RefSeq (protein)

NP_055108

n/a

Location (UCSC)Chr 22: 38.82 – 38.84 MbChr 15: 79.79 – 79.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal pentraxin receptor is a protein that in humans is encoded by the NPTXR gene.[5][6]

This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat protein pentraxin is thought to mediate neuronal uptake of synaptic material and the presynaptic snake venom toxin, taipoxin. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for human and mouse, based on strong sequence conservation amongst these species.[6]

See also

  • NPTX2, Neuronal pentraxin II

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000221890 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022421 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Andersson KB, Florholmen G, Winer LH, Tonnessen T, Christensen G (Feb 2006). "Regulation of neuronal type genes in congestive heart failure rats". Acta Physiol (Oxf). 186 (1): 17–27. doi:10.1111/j.1748-1716.2005.01503.x. PMID 16497176.
  6. 1 2 "Entrez Gene: NPTXR neuronal pentraxin receptor".

Further reading

  • Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
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