NPM3

NPM3
Identifiers
AliasesNPM3, PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3
External IDsMGI: 894653 HomoloGene: 5083 GeneCards: NPM3
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.32Start101,781,325 bp[1]
End101,783,413 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10360

18150

Ensembl

ENSG00000107833

ENSMUSG00000056209

UniProt

O75607

Q9CPP0

RefSeq (mRNA)

NM_006993

NM_008723

RefSeq (protein)

NP_008924

NP_032749

Location (UCSC)Chr 10: 101.78 – 101.78 MbChr 19: 45.75 – 45.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene.[5][6]

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000107833 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056209 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi:10.1186/1471-2164-2-8. PMC 60000. PMID 11722795.
  6. 1 2 "Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".

Further reading

  • Philpott A, Krude T, Laskey RA (2000). "Nuclear chaperones". Semin. Cell Dev. Biol. 11 (1): 7–14. doi:10.1006/scdb.1999.0346. PMID 10736259.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • MacArthur CA, Shackleford GM (1997). "Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin". Genomics. 42 (1): 137–40. doi:10.1006/geno.1997.4353. PMID 9177783.


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