NME1-NME2

NME1-NME2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3BBB, 3BBF, 1NSK, 3BBC, 1NUE
Identifiers
Aliases	NME1-NME2, NM23-LV, NMELV, NME1-NME2 readthrough
External IDs	MGI: 3648428 HomoloGene: 39553 GeneCards: NME1-NME2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 51,153,590 bp[1] End 51,171,744 bp[1]
Gene ontology Molecular function • transferase activity • DNA binding • nucleotide binding • protein histidine kinase activity • transcription factor activity, sequence-specific DNA binding • metal ion binding • kinase activity • protein binding • ATP binding • nucleoside diphosphate kinase activity • protein serine/threonine kinase activity • fatty acid binding • drug binding • intermediate filament binding • enzyme binding Cellular component • cytoplasm • cytosol • cell projection • focal adhesion • ruffle • extracellular exosome • cell nucleus • cell periphery • lamellipodium • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • intermediate filament • mitochondrial membrane • perinuclear region of cytoplasm Biological process • UTP biosynthetic process • peptidyl-histidine phosphorylation • nucleobase-containing small molecule interconversion • CTP biosynthetic process • regulation of transcription, DNA-templated • phosphorylation • positive regulation of epithelial cell proliferation • positive regulation of keratinocyte differentiation • negative regulation of apoptotic process • nucleotide metabolic process • nucleoside diphosphate phosphorylation • transcription, DNA-templated • cell adhesion • nucleoside triphosphate biosynthetic process • integrin-mediated signaling pathway • GTP biosynthetic process • regulation of epidermis development • positive regulation of transcription from RNA polymerase II promoter • neutrophil degranulation • negative regulation of myeloid leukocyte differentiation • positive regulation of neuron projection development • positive regulation of cAMP biosynthetic process • cellular response to oxidative stress • protein autophosphorylation • protein oligomerization • response to growth hormone • cellular response to glucose stimulus • cellular response to fatty acid Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	654364	433968
Ensembl	ENSG00000011052	n/a
UniProt	P22392	n/a
RefSeq (mRNA)	NM_001018136	n/a
RefSeq (protein)	NP_001018146	n/a
Location (UCSC)	Chr 17: 51.15 – 51.17 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

NM23-LV, also known as NME1-NME2, is a human gene.^[4]

The NME1-NME2 mRNA is a naturally occurring co-transcribed product of the neighboring NME1 and NME2 genes. The significance of this co-transcribed mRNA and the function of its predicted protein product have not yet been determined. Alternative splicing of this gene results in different transcript variants encoding distinct isoforms, but the full-length nature of each variant has not been defined.^[4]

References

Further reading