NKRF (gene)

NKRF
Identifiers
AliasesNKRF, ITBA4, NRF, NFKB repressing factor
External IDsMGI: 1924536 HomoloGene: 84816 GeneCards: NKRF
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq24Start119,588,337 bp[1]
End119,605,895 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55922

77286

Ensembl

ENSG00000186416

ENSMUSG00000044149

UniProt

O15226

Q8BY02

RefSeq (mRNA)

NM_001173487
NM_001173488
NM_017544

NM_029891

RefSeq (protein)

NP_001166958
NP_001166959
NP_060014

NP_084167

Location (UCSC)Chr X: 119.59 – 119.61 MbChr X: 36.89 – 36.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.[5][6]

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186416 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044149 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
  6. 1 2 "Entrez Gene: NKRF NF-kappaB repressing factor".

Further reading

  • Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25". Gene. 192 (2): 291–8. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902.
  • Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. doi:10.1073/pnas.212306199. PMC 137863. PMID 12381793.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor". Mol. Cells. 16 (3): 397–401. PMID 14744032.
  • Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF". J. Cell Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMC 1190279. PMID 16107696.
  • Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550.
  • Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element". RNA. 13 (8): 1328–40. doi:10.1261/rna.545407. PMC 1924892. PMID 17592041.


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