NGFRAP1

BEX3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBEX3, Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDsMGI: 1338016 HomoloGene: 7642 GeneCards: BEX3
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq22.2Start103,376,340 bp[1]
End103,378,077 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27018

12070

Ensembl

ENSG00000166681

ENSMUSG00000046432

UniProt

Q00994

Q9WTZ9

RefSeq (mRNA)

NM_206917
NM_001282674
NM_014380
NM_206915

NM_001110233
NM_001110234
NM_009750

RefSeq (protein)

NP_001269603
NP_055195
NP_996798
NP_996800

NP_001103703
NP_001103704
NP_033880

Location (UCSC)Chr X: 103.38 – 103.38 MbChr X: 136.27 – 136.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.[5][6][7]

Interactions

NGFRAP1 has been shown to interact with YWHAE[8] and Low affinity nerve growth factor receptor.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166681 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046432 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727.
  6. ↑ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. PMID 2171551.
  7. ↑ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".
  8. ↑ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.

Further reading

  • Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
  • Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
  • Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233.
  • Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738.
  • Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
  • Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582.
  • Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005.
  • Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455.
  • Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077.
  • Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.


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