NEDD1

NEDD1
Identifiers
AliasesNEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1
External IDsMGI: 97293 HomoloGene: 7439 GeneCards: NEDD1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q23.1Start96,907,223 bp[1]
End96,953,777 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

121441

17997

Ensembl

ENSG00000139350

ENSMUSG00000019988

UniProt

Q8NHV4

P33215

RefSeq (mRNA)

NM_001135175
NM_001135176
NM_001135177
NM_152905

NM_008682

RefSeq (protein)

NP_001128647
NP_001128648
NP_001128649
NP_690869

NP_032708

Location (UCSC)Chr 12: 96.91 – 96.95 MbChr 10: 92.68 – 92.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene [5] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139350 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019988 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading

  • Pinyol R, Scrofani J, Vernos I (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function". Curr. Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. PMID 23273898.
  • Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome". Curr. Biol. 22 (16): 1516–23. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
  • Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
  • Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099.
  • Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034.


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