NDUFV3

NDUFV3
Identifiers
AliasesNDUFV3, CI-10k, CI-9KD, NADH:ubiquinone oxidoreductase subunit V3
External IDsMGI: 1890894 HomoloGene: 10885 GeneCards: NDUFV3
Gene location (Human)
Chr.Chromosome 21 (human)[1]
Band21q22.3Start42,879,644 bp[1]
End42,913,304 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4731

78330

Ensembl

ENSG00000160194

ENSMUSG00000024038

UniProt

P56181

Q8BK30

RefSeq (mRNA)

NM_001001503
NM_021075

NM_001083891
NM_030087

RefSeq (protein)

NP_001001503
NP_066553

NP_001077360
NP_084363

Location (UCSC)Chr 21: 42.88 – 42.91 MbChr 17: 31.52 – 31.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.[5][6]

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160194 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024038 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ de Coo RF, Buddiger P, Smeets HJ, van Oost BA (Feb 1998). "Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3)". Genomics. 45 (2): 434–7. doi:10.1006/geno.1997.4930. PMID 9344673.
  6. 1 2 "Entrez Gene: NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa".

Further reading

  • Sled VD, Vinogradov AD (1993). "Kinetics of the mitochondrial NADH-ubiquinone oxidoreductase interaction with hexammineruthenium(III)". Biochim. Biophys. Acta. 1141 (2–3): 262–8. doi:10.1016/0005-2728(93)90051-G. PMID 8443212.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Loeffen JL, Triepels RH, van den Heuvel LP, et al. (1999). "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed". Biochem. Biophys. Res. Commun. 253 (2): 415–22. doi:10.1006/bbrc.1998.9786. PMID 9878551.
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • Berry A, Scott HS, Kudoh J, et al. (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics. 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zakharova NV, Zharova TV (2003). "Kinetic mechanism of mitochondrial NADH:ubiquinone oxidoreductase interaction with nucleotide substrates of the transhydrogenase reaction". Biochemistry Mosc. 67 (12): 1395–404. doi:10.1023/A:1021818312040. PMID 12600270.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kervinen M, Hinttala R, Helander HM, et al. (2006). "The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I". Hum. Mol. Genet. 15 (17): 2543–52. doi:10.1093/hmg/ddl176. PMID 16849371.


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