NDST2

NDST2
Identifiers
AliasesNDST2, HSST2, NST2, N-deacetylase/N-sulfotransferase 2, N-deacetylase and N-sulfotransferase 2
External IDsMGI: 97040 HomoloGene: 20803 GeneCards: NDST2
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8509

17423

Ensembl

n/a

ENSMUSG00000039308

UniProt

P52849

P52850

RefSeq (mRNA)

NM_001330107
NM_003635

NM_010811

RefSeq (protein)

NP_001317036
NP_003626

NP_034941

Location (UCSC)n/aChr 14: 20.72 – 20.73 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.[4][5]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039308 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Humphries DE, Lanciotti J, Karlinsky JB (Jul 1998). "cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2". Biochem J. 332 (2): 303–7. PMC 1219482. PMID 9601056.
  5. ↑ "Entrez Gene: NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2".

Further reading

  • Esko JD, Selleck SB (2002). "Order out of chaos: assembly of ligand binding sites in heparan sulfate". Annu. Rev. Biochem. 71: 435–71. doi:10.1146/annurev.biochem.71.110601.135458. PMID 12045103.
  • Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
  • Forsberg E, Pejler G, Ringvall M, et al. (1999). "Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme". Nature. 400 (6746): 773–6. doi:10.1038/23488. PMID 10466727.
  • Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Duncan MB, Liu M, Fox C, Liu J (2006). "Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2". Biochem. Biophys. Res. Commun. 339 (4): 1232–7. doi:10.1016/j.bbrc.2005.11.142. PMID 16343444.


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