NAPSA

NAPSA
Identifiers
AliasesNAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin A aspartic peptidase
External IDsMGI: 109365 HomoloGene: 68418 GeneCards: NAPSA
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start50,358,477 bp[1]
End50,365,830 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

9476

16541

Ensembl

ENSG00000131400

ENSMUSG00000002204

UniProt

O96009

O09043

RefSeq (mRNA)

NM_004851

NM_008437

RefSeq (protein)

NP_004842

NP_032463

Location (UCSC)Chr 19: 50.36 – 50.37 MbChr 7: 44.57 – 44.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Napsin-A is a protein that is encoded in humans by the NAPSA gene. [5]

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000131400 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002204 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: NAPSA napsin A aspartic peptidase".

Further reading

  • Koelsch G, Mares M, Metcalf P, Fusek M (1994). "Multiple functions of pro-parts of aspartic proteinase zymogens". FEBS Lett. 343 (1): 6–10. doi:10.1016/0014-5793(94)80596-2. PMID 8163018.
  • Blundell TL, Guruprasad K, Albert A, et al. (1998). "The aspartic proteinases. An historical overview". Adv. Exp. Med. Biol. 436: 1–13. doi:10.1007/978-1-4615-5373-1_1. PMID 9561193.
  • Tatnell PJ, Powell DJ, Hill J, et al. (1999). "Napsins: new human aspartic proteinases. Distinction between two closely related genes". FEBS Lett. 441 (1): 43–8. doi:10.1016/S0014-5793(98)01522-1. PMID 9877162.
  • Chuman Y, Bergman A, Ueno T, et al. (2000). "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas". FEBS Lett. 462 (1–2): 129–34. doi:10.1016/S0014-5793(99)01493-3. PMID 10580105.
  • Schauer-Vukasinovic V, Bur D, Kling D, et al. (2000). "Human napsin A: expression, immunochemical detection, and tissue localization". FEBS Lett. 462 (1–2): 135–9. doi:10.1016/S0014-5793(99)01458-1. PMID 10580106.
  • Yan R, Bienkowski MJ, Shuck ME, et al. (1999). "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity". Nature. 402 (6761): 533–7. doi:10.1038/990107. PMID 10591213.
  • Cook M, Bühling F, Ansorge S, et al. (2002). "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells". Biochim. Biophys. Acta. 1577 (1): 10–6. doi:10.1016/s0167-4781(02)00400-1. PMID 12151090.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ueno T, Linder S, Elmberger G (2004). "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma". Br. J. Cancer. 88 (8): 1229–33. doi:10.1038/sj.bjc.6600879. PMC 2747556. PMID 12698189.
  • Brasch F, Ochs M, Kahne T, et al. (2004). "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung". J. Biol. Chem. 278 (49): 49006–14. doi:10.1074/jbc.M306844200. PMID 13129928.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Innocenti M, Zucconi A, Disanza A, et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.
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