Myod family inhibitor domain containing

MDFIC
Identifiers
Aliases	MDFIC, HIC, MyoD family inhibitor domain containing, MDFIC1
External IDs	MGI: 104611 HomoloGene: 18404 GeneCards: MDFIC
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.1-q31.2 Start 114,922,154 bp[1] End 115,019,202 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A1 Start 15,720,661 bp[2] End 15,802,169 bp[2]
Gene ontology Molecular function • transcription factor binding • Tat protein binding • protein binding • cyclin binding Cellular component • nucleolus • cell nucleus • cytoplasm • Golgi apparatus • nucleoplasm Biological process • positive regulation of transcription, DNA-templated • positive regulation of viral transcription • regulation of Wnt signaling pathway • viral process • regulation of transcription, DNA-templated • activation of JUN kinase activity • transcription, DNA-templated • negative regulation of protein import into nucleus • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29969	16543
Ensembl	ENSG00000135272	ENSMUSG00000041390
UniProt	Q9P1T7	Q8BX65
RefSeq (mRNA)	NM_199072 NM_001166345 NM_001166346	NM_175088
RefSeq (protein)	NP_001159817 NP_001159818 NP_951038	NP_780297
Location (UCSC)	Chr 7: 114.92 – 115.02 Mb	Chr 6: 15.72 – 15.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. ^[5]

Function

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.