Mitochondrial ribosomal protein l13
Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. [5]
Function
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000172172 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022370 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: Mitochondrial ribosomal protein L13". Retrieved 2017-07-05.
Further reading
- Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC 2644327. PMID 18995835.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.