Mitochondrial fission factor

MFF
Identifiers
Aliases	MFF, C2orf33, GL004, mitochondrial fission factor, EMPF2
External IDs	HomoloGene: 137341 GeneCards: MFF
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	227,357,836 bp[1]
Gene ontology
Molecular function	• protein homodimerization activity; • protein binding;
Cellular component	• integral component of membrane; • membrane; • synaptic vesicle; • peroxisome; • synapse; • mitochondrial outer membrane; • cell junction; • integral component of mitochondrial membrane; • cytoplasmic vesicle; • mitochondrion;
Biological process	• mitochondrial fusion; • mitochondrial fragmentation involved in apoptotic process; • positive regulation of mitochondrial fission; • mitochondrial fission; • regulation of mitochondrion organization; • regulation of peroxisome organization; • protein targeting to mitochondrion; • peroxisome fission; • positive regulation of release of cytochrome c from mitochondria; • mitochondrion morphogenesis; • protein homooligomerization; • release of cytochrome c from mitochondria; • positive regulation of protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	56947
	n/a
	ENSG00000168958
	n/a
	Q9GZY8
	n/a
NM_001277061; NM_001277062; NM_001277063; NM_001277064; NM_001277065;
	NM_001277066; NM_001277067; NM_001277068; NM_020194
	n/a
NP_001263990; NP_001263991; NP_001263992; NP_001263993; NP_001263994;
	NP_001263995; NP_001263996; NP_001263997; NP_064579
	n/a
	Wikidata
View/Edit Human

Mitochondrial fission factor (Mff) is a protein that in humans is encoded by the MFF gene.^[3]

Mff is an outer mitochondrial membrane protein that binds to the Drp1 GTPase that controls mitochondrial fission. The Mff-Drp1 complex promotes mitochondrial fission.^[4] Mff also regulates peroxisome morphology.^[5]

References