Mir-744 microRNA precursor family

mir-744
Identifiers
Symbol mir-744
Rfam RF00936
miRBase family MIPF0000431
Other data
RNA type microRNA
Domain(s) Eukaryota;
PDB structures PDBe

In molecular biology mir-744 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-744 and cancer in mice

miR-744 plays a role in tumour development and growth in mouse cell lines. Its expression induces cyclin B1 expression, whilst knockdown sees a resultant decreased level of mouse cyclin B through the Ccnb1 gene.[1] Short-term overexpression of miR-744 in mouse cell lines has been seen to enhance cell proliferation, whilst chromosomal instability and in vivo suppression are concurrent with a prolonged expression.

TGF-β1 repression

Multiple miR-744 binding sites have been identified in the proximal 3' untranslated region of transforming growth factor beta 1 (TGF-β1). Direct targeting of TGF-β1 by miR-744 has been identified, and transfection is seen to inhibit endogenous TGF-β1 synthesis by directing post-transcriptional regulation.[2]

EEF1A2 repression

miR-744 directly targets translation elongation factor and known protooncogene EEF1A2.[3] mIR-744 also upregulates during resveratrol treatment of MCF7 breast cancer cells.[4]

See also

References

  1. ↑ Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, et al. (2012). "Upregulation of Cyclin B1 by miRNA and its implications in cancer". Nucleic Acids Res. 40 (4): 1695–707. doi:10.1093/nar/gkr934. PMC 3287204. PMID 22053081.
  2. ↑ Martin J, Jenkins RH, Bennagi R, Krupa A, Phillips AO, Bowen T, et al. (2011). "Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744". PLoS ONE. 6 (10): e25044. doi:10.1371/journal.pone.0025044. PMC 3186795. PMID 21991303.
  3. ↑ Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.
  4. ↑ Vislovukh, A; Kratassiouk, G; Porto, E; Gralievska, N; Beldiman, C; Pinna, G; El'skaya, A; Harel-Bellan, A; Negrutskii, B; Groisman, I (11 June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.

Further reading

  • Song, M. Y.; Pan, K. F.; Su, H. J.; Zhang, L.; Ma, J. L.; Li, J. Y.; Yuasa, Y.; Kang, D.; Kim, Y. S.; You, W. C. (2012). Califano, Joseph, ed. "Identification of Serum MicroRNAs as Novel Non-Invasive Biomarkers for Early Detection of Gastric Cancer". PLoS ONE. 7 (3): e33608. doi:10.1371/journal.pone.0033608. PMC 3303856. PMID 22432036.
  • Mi, Q. S.; Weiland, M.; Qi, R. Q.; Gao, X. H.; Poisson, L. M.; Zhou, L. (2012). Homberg, Judith, ed. "Identification of Mouse Serum miRNA Endogenous References by Global Gene Expression Profiles". PLoS ONE. 7 (2): e31278. doi:10.1371/journal.pone.0031278. PMC 3277497. PMID 22348064.
  • Chen, Y. Q.; Wang, X. X.; Yao, X. M.; Zhang, D. L.; Yang, X. F.; Tian, S. F.; Wang, N. S. (2012). "Abated microRNA-195 expression protected mesangial cells from apoptosis in early diabetic renal injury in mice". Journal of Nephrology. 25 (4): 566–576. doi:10.5301/jn.5000034. PMID 21983986.
  • Yoke-Kqueen, C.; Yoke-Kqueen, C.; Sabariah, A. R.; Shiran, M. S.; Singh, A.; Learn-Han, L. (2011). "Differential microRNA expression and identification of putative miRNA targets and pathways in head and neck cancers". International Journal of Molecular Medicine. 28 (3): 327–336. doi:10.3892/ijmm.2011.714. PMID 21637912.


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