mir-135 microRNA precursor family

mir-135 microRNA precursor family
Identifiers
Symbol mir-135
Rfam RF00246
miRBase MI0000452
miRBase family MIPF0000028
Other data
RNA type Gene; miRNA
Domain(s) Eukaryota
GO 0035195 0035068
SO 0001244
PDB structures PDBe

The miR-135 microRNA precursor is a small non-coding RNA that is involved in regulating gene expression. It has been shown to be expressed in human, mouse and rat.[1][2] miR-135 has now been predicted or experimentally confirmed in a wide range of vertebrate species (MIPF0000028). Precursor microRNAs are ~70 nucleotides in length and are processed by the Dicer enzyme to produce the shorter 21-24 nucleotide mature sequence. In this case the mature sequence is excised from the 5' arm of the hairpin.

Targets of miR-135

  • Nagel et al.. showed that miR-135a and b target the 3' untranslated region of the APC gene.[3]

References

  1. ↑ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735&ndash, 739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
  2. ↑ Kim, J; Krichevsky A; Grad Y; Hayes GD; Kosik KS; Church GM; Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA. 101 (1): 360&ndash, 365. Bibcode:2003PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248.
  3. ↑ Nagel R, le Sage C, Diosdado B, et al. (July 2008). "Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer". Cancer Research. 68 (14): 5795–802. doi:10.1158/0008-5472.CAN-08-0951. PMID 18632633.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.