McN5652
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Names | |
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IUPAC name
rel-(6R,10bS)-6-[4-(Methylsulfanyl)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | |
Other names
trans-McN-5652 | |
Identifiers | |
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3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
PubChem CID |
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Properties | |
C19H21NS | |
Molar mass | 295.44 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
McN5652[1] is a molecule that can be radiolabeled and then used as a radioligand in positron emission tomography (PET) studies. The [11C]-(+)-McN5652 enantiomer binds to the serotonin transporter.[2] The radioligand is used for molecular neuroimaging and for imaging of the lungs.[3]
It was developed by Johnson & Johnson's McNeil Laboratories. According to McNeil, McN5652 was the strongest SRI ever reported at the time of its discovery (sub nM Ki). However, it is not completely 5-HT selective: the racemate has 0.68, 2.9, and 36.8 nM (SNDRI Ki) whereas (+)-enantiomer has 0.39, 1.8, and 23.5 nM (SNDRI Ki). Paroxetine was listed as 0.44 nM, 20, and 460 Ki in the same paper by he same authors.
See also
- DASB
- JNJ-7925476 (p-ethynyl)
References
- ↑ US 4595688 Certain Hexahydro-6-Arylprylpyrrolo [2,1-A]Isoquinoline
- ↑ M. Suehiro; U. Scheffel; H. T. Ravert; R. F. Dannals; H. N. Jr Wagner (1993). "[11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET". Life Sciences. 53 (11): 883–92. doi:10.1016/0024-3205(93)90440-E. PMID 8366755.
- ↑ Akihiro Takano; Hiroshi Ito; Yasuhiko Sudo; Makoto Inoue; Tetsuya Ichimiya; Fumihiko Yasuno; Kazutoshi Suzuki; Tetsuya Suhara (August 2007). "Effects of smoking on the lung accumulation of [11C]McN5652". Annals of Nuclear Medicine. 21 (6): 349–54. doi:10.1007/s12149-007-0031-1. PMID 17705015.
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