Markus Grompe

Markus Grompe

Markus Grompe is a professor of Pediatrics, director of the Papé Family Pediatric Institute and the Oregon Stem Cell Center, practicing physician at Oregon Health & Science University[1]. He also holds the Ray Hickey Endowed Chair at Doernbecher Children's Hospital.[2]

Grompe is a specialist in hepatology and stem cell biology, and is known for the development of the "Fah mouse model", a transgenic mouse with an inactivating mutation (exon 5 deletion) in sequence encoding fumarylacetoacetate hydrolase (Fah).[3] This mouse strain has been a useful model of Type I tyrosinemia, a human genetic disease caused by inactivating mutations in the Fah gene. The mice have been used to model diseases such as malaria and to optimize human gene therapy strategies

Dr. Grompe has made major contributions to the study of Fanconi Anemia. His contributions to the study of this rare hematological deficiency has helped to reveal the contributions of the FANC protein complexes associated with the repair of double-stranded breaks in genomic DNA.

Markus Grompe is the founder of and scientific consultant for Yecuris Inc that distributes mice with "humanized" livers to pharmaceutical and biotech companies for pre-clinical research in infectious liver diseases, liver gene therapy, and drug metabolism.[4]

References

  1. ↑ "Health Care provider Markus Grompe, M.D. - OHSU Health Care". Oregon Health & Science University.
  2. ↑ "Grompe appointed chair". Oregon Health & Science University.
  3. ↑ Grompe et al., Genes Dev. 1993 Dec 7(12A):2298-307
  4. ↑ "company". www.yecuris.com.


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