Maneesha S. Inamdar

Maneesha S. Inamdar
Born (1967-02-25) 25 February 1967
India
Residence Bengaluru, Karnataka, India
Nationality Indian
Alma mater
Known for Studies in comparative analysis of cardiovascular development and stem cells
Awards
Scientific career
Fields
Institutions

Maneesha S. Inamdar (born 25 February 1967) is an Indian stem cell and developmental biologist and a professor and dean at the Molecular Biology and Genetics Unit of the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR). She is also an adjunct professor at the Institute for Stem Cell Biology and Regenerative Medicine (inStem) and an elected fellow of the Indian Academy of Sciences and the Indian National Science Academy. She is known to have pioneered stem cell research in India using human embryonic stem cell-derived models. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences, in 2011.[1]

Biography

Tata Institute of Fundamental Research

Maneesha Inamdar, born on 25 February 1967, did her doctoral studies in molecular biology at Tata Institute of Fundamental Research (TIFR) and completed her post-doctoral work in cardiovascular biology at the University of North Carolina at Chapel Hill. Subsequently, she joined Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) as a member of the faculty where she holds the position of a professor of the Molecular Biology and Genetics Unit of the institution and dean, Fellowships and Extension Programmes. At JNCASR, she has established her laboratory for stem cell research and hosts several research scholars, postdoctoral fellows, trainees and collaborators.[2] She also serves as an adjunct faculty at the Institute for Stem Cell Biology and Regenerative Medicine (inStem).[3]

Career

CRISPR modulated stem cell lines
Mouse embryo vasculature

Inamdar is a Professor at the Molecular Biology and Genetics Unit, JNCASR, Bangalore. Inamdar’s group is unravelling the basic biology of stem cells with the goal of contributing to strategies to control and manipulate them effectively for applications in cell therapy and regenerative medicine.

The group led by her developed normal stem cell lines from defective embryos and these have been deposited at the UK Stem Cell Bank.[4] Their efforts have been included in the International Stem Cell Forum (ISCI2) initiatives and they represent the sole contribution of India in these initiatives. Inamdar is also working on the development of regenerative therapeutic methods by collecting patient-derived induced pluripotent stem cells (iPS) for which they have generated mouse and human induced iPS cells. Her studies have been documented by way of a number of articles and resource materials.[5]

She has multiple national and international collaborations and grants with scientists in USA, UK and France. Inamdar has carried out projects for the Department of Biotechnology, the Department of Science and Technology, the Council of Scientific and Industrial Research and other international agencies including the UK-India Education and Research Initiative (UKIERI), Indo-US Science and Technology Forum (IUSSTF), The Wellcome Trust, UK, the DBT-Indo-Danish programme and the Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA).[6] She is also a member or life member of the Indian Society of Cell Biology,[7] the Society for Developmental Biology, USA, the International Society for Stem Cell Research (ISSCR), the North American Vascular Biology Organization (NAVBO) and the Indian Society of Developmental Biologists.[8]

She represents India in the International Stem Cell Initiative (ISCI) and the International Stem Cell Banking Initiative (ISCBI) where she is also a member of the steering group. She also serves as an expert and advisor in various capacities in several national and international committees including hESC Registry Europe, International Stem Cell Registry, Europe. She is Chairperson or a member of several national and institutional advisory and review committees for ethics and stem cell research.

Awards and honors

Inamdar was selected as a Young Associate of the Indian Academy of Sciences in 1999, with the tenure running until 2002.[9] The Department of Biotechnology (DBT) of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards in 2011.[1] She was also awarded the National Women Bioscientist Award, in 2011. The Indian Academy of Sciences honored her again with elected fellowship in 2017.[10] She was also elected Fellow of the Indian National Science Academy in 2018. She was awarded the prestigious Dr Kalpana Chawla Award for 2017.[11][12]

Selected bibliography

  • Shetty, Deeti K.; Kalamkar, Kaustubh P.; Inamdar, Maneesha S. (2018-07). "OCIAD1 Controls Electron Transport Chain Complex I Activity to Regulate Energy Metabolism in Human Pluripotent Stem Cells". Stem Cell Reports. 11 (1): 128–141. doi:10.1016/j.stemcr.2018.05.015. ISSN 2213-6711.
  • Shetty, Ronak; Joshi, Divyesh; Jain, Mamta; Vasudevan, Madavan; Paul, Jasper Chrysolite; Bhat, Ganesh; Banerjee, Poulomi; Abe, Takaya; Kiyonari, Hiroshi (2018-04-04). "Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning".Scientific Reports. 8 (1). doi:10.1038/s41598-018-24014-w. ISSN 2045-2322. PMC 5884795 . PMID 29618843.
  • Ranganath, Sudhir H.; Tong, Zhixiang; Levy, Oren; Martyn, Keir; Karp, Jeffrey M.; Inamdar, Maneesha S. (2016-06). "Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering". Stem Cell Reports. 6 (6): 926–939. doi:10.1016/j.stemcr.2016.05.003. ISSN 2213-6711.
  • Shetty, Deeti K.; Inamdar, Maneesha S. (2016-03). "Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-39". Stem Cell Research. 16 (2): 308–310. doi:10.1016/j.scr.2015.12.037. ISSN 1873-5061.
  • Khadilkar, Rohan J.; Rodrigues, Diana; Mote, Ridim Dadasaheb; Sinha, Arghyashree Roychowdhury; Kulkarni, Vani; Magadi, Srivathsa Subramanya; Inamdar, Maneesha S. (2014-03-18). "ARF1–GTP regulates Asrij to provide endocytic control ofDrosophilablood cell homeostasis". Proceedings of the National Academy of Sciences. 111 (13): 4898–4903. doi:10.1073/pnas.1303559111. ISSN 0027-8424.
  • Inamdar, Maneesha S.; Healy, Lyn; Sinha, Abhishek; Stacey, Glyn (2011-10-29). "Global Solutions to the Challenges of Setting up and Managing a Stem Cell Laboratory". Stem Cell Reviews and Reports. 8 (3): 830–843. doi:10.1007/s12015-011-9326-7. ISSN 1550-8943.
  • "Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage". Nature Biotechnology. 29 (12): 1132–1144. 2011-11-27. doi:10.1038/nbt.2051. ISSN 1087-0156.
  • Inamdar, Maneesha S.; Venu, Parvathy; Srinivas, M.S.; Rao, Kamini; VijayRaghavan, K. (2009-04). "Derivation and Characterization of Two Sibling Human Embryonic Stem Cell Lines From Discarded Grade III Embryos". Stem Cells and Development. 18 (3): 423–434. doi:10.1089/scd.2008.0131. ISSN 1547-3287.

See also

Notes

    References

    1. 1 2 ""Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016. Retrieved 2017-11-20" (PDF). 2016. Retrieved 2018-08-01.
    2. ↑ "Maneesha Inamdar - Research Group". www.jncasr.ac.in. Retrieved 2018-08-01.
    3. ↑ "Faculty | InStem". instem.res.in. Retrieved 2018-08-01.
    4. ↑ "Maneesha Inamdar - Academic profile". www.jncasr.ac.in. Retrieved 2018-08-01.
    5. ↑ "Maneesha Inamdar - Publications". www.jncasr.ac.in. Retrieved 2018-08-01.
    6. ↑ ""Ensemble - Newsletter of the Indo-French Centre for the Promotion of Advanced Research" (PDF) (Press release). New Delhi: Indo-French Centre for the Promotion of Advanced Research. 2017. Mobility of Scientists / Researchers supported under CEFIPRA projects during January–March, 2017" (PDF). www.jncasr.ac.in. Retrieved 2018-08-01.
    7. ↑ "ISCB Home Page". www.iscb.org.in. Retrieved 2018-08-01.
    8. ↑ "InSDB :: Indian Society for Developmetal Biologist". www.devbioindia.org. Retrieved 2018-08-01.
    9. ↑ "Associateship | Indian Academy of Sciences". www.ias.ac.in. Retrieved 2018-08-01.
    10. ↑ "Fellowship | Indian Academy of Sciences". www.ias.ac.in. Retrieved 2018-08-01.
    11. ↑ "Innovation in science need of the hour: CM". Deccan Herald. 2018-08-07. Retrieved 2018-08-08.
    12. ↑ "KSCST : State Science and Technology Awards - 2017". www.kscst.iisc.ernet.in. Retrieved 2018-08-08.
    • "Panel of Reviewers" (PDF). Indian Journal of Medical Research. 2015. Retrieved 2018-01-29.
    • "Stem cells for the treatment of diseases". abc.org. 6 September 2011. Retrieved 29 January 2018.
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