Mandë Holford

Mandë Holford
Alma mater
Scientific career
Fields
Institutions
Thesis Site-Specific Incorporation of Biochemical and Biophysical Probes into Proteins Using Expressed Protein Ligation (2002)
Doctoral advisor Tom Muir
Website holfordlab.com

Mandë Holford is an Associate Professor in Chemistry at Hunter College with scientific appointments at the American Museum of Natural History and Weill Cornell Medical College.[1][2]

Education and career

Holford received her BS in mathematics and chemistry from York College, City University of New York and her PhD from The Rockefeller University.[3] She did her postdoctoral research at The University of Utah in the lab of Baldomero Olivera.[4] She was also a Science & Technology Policy Fellow through the American Association for the Advancement of Science.[5] During her fellowship she worked under Kerri-Ann Jones in the National Science Foundation's Office of International Science and Engineering.

Research

Holford summarizes her research interests as moving "from mollusks to medicine" for drug discovery and delivery.[6][7] She and her research team extract peptides from venomous snails to identify possible treatments for pain and cancer.[8] Her work takes an interdisciplinary approach, leveraging biochemistry, genomics, proteomics, evolution, and cell biology to isolate, identify, and characterize novel venomous peptides and devise drug delivery strategies.[9][10]

Science diplomacy

Holford was first trained in science diplomacy as an AAAS Science & Technology Policy fellow at the National Science Foundation.[5][11] Since that time, she has worked on several projects and initiatives to encourage early career scientists to think globally about their research impacts. These efforts include the Hurford Science Diplomacy Initiative, which is a six-week long program taught at The Rockefeller University by Jesse H. Ausubel, Rod Nichols, and Dr. Holford.[12][13] She has also worked with the AAAS Center for Science Diplomacy on their programs to train scientists for global leadership and advocacy.[14]

Her writing on the importance of training young scientists to leverage their expertise to build global connections has been featured in the World Science Forum and Scientific American.[15][16] She has also written about the role scientists played in re-establishing connections with Cuba in 2015 for Science magazine.[17]

Holford is a life member of the Council on Foreign Relations.[18]

Public engagement

Holford is actively involved in science education and is the co-founder of KillerSnails.com, a learning games company supported by the National Science Foundation and the Small Business Innovation Research Fund.[19][20] They have produced games like Killer Snails: Assassins of the Sea and Biome Builder, which won the International Serious Play Gold Medal.[21] She has also appeared on The Moth, Science Friday, NBC Learn, and You're the Expert, speaking about her research expertise and her experiences as a scientist.[22][23][24][25]

Awards and honors

References

  1. ↑ "Mandë Holford, Ph.D. — Hunter College". www.hunter.cuny.edu. Retrieved 2018-06-17.
  2. ↑ "Holford, Mande". vivo.med.cornell.edu. Retrieved 2018-06-17.
  3. ↑ Mande, Holford, (2002). Site-Specific Incorporation of Biochemical and Biophysical Probes into Proteins Using Expressed Protein Ligation (Thesis). Rockefeller University.
  4. ↑ Holford, Mandë; Zhang, Min-Min; Gowd, Konkallu; Azam, Layla; Green, Brad; Watkins, Maren; Ownby, John-Paul; Yoshikami, Doju; Bulaj, Grzegorz (2008-11-01). "Pruning Nature: Biodiversity-Derived Discovery of Novel Sodium Channel Blocking Conotoxins from Conus bullatus". Toxicon. 53: 90–8. doi:10.1016/j.toxicon.2008.10.017. PMC 2677393.
  5. 1 2 "Mande Holford". AAAS - The World's Largest General Scientific Society. 2013-06-14. Retrieved 2018-06-17.
  6. ↑ Verdes, Aida; Anand, Prachi; Gorson, Juliette; Jannetti, Stephen; Kelly, Patrick; Leffler, Abba; Simpson, Danny; Ramrattan, Girish; Holford, Mandë (2016-04-19). "From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins". Toxins. 8 (4): 117. doi:10.3390/toxins8040117.
  7. ↑ Kelly, Patrick; Anand, Prachi; Uvaydov, Alexander; Chakravartula, Srinivas; Sherpa, Chhime; Pires, Elena; O’Neil, Alison; Douglas, Trevor; Holford, Mandë (2015-10-09). "Developing a Dissociative Nanocontainer for Peptide Drug Delivery". International Journal of Environmental Research and Public Health. 12 (10): 12543–12555. doi:10.3390/ijerph121012543.
  8. ↑ "Prospecting for Painkillers". The Scientist. Retrieved 2018-06-17.
  9. ↑ Anand, Prachi; O’Neil, Alison; Lin, Emily; Douglas, Trevor; Holford, Mandë (2015-08-03). "Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers". Scientific Reports. 5 (1). doi:10.1038/srep12497. ISSN 2045-2322.
  10. ↑ Leffler, Abba E.; Kuryatov, Alexander; Zebroski, Henry A.; Powell, Susan R.; Filipenko, Petr; Hussein, Adel K.; Gorson, Juliette; Heizmann, Anna; Lyskov, Sergey (2017-09-05). "Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models". Proceedings of the National Academy of Sciences: 201703952. doi:10.1073/pnas.1703952114. ISSN 0027-8424. PMID 28874590.
  11. ↑ "International Activities and the US National Science Foundation". Retrieved 2018-06-17.
  12. ↑ "The Rockefeller University » Science Diplomacy". graduate.rockefeller.edu. Retrieved 2018-06-17.
  13. ↑ "The Challenge of Building Science Diplomacy Capabilities for Early Career Academic Investigators". Science & Diplomacy. Retrieved 2018-06-17.
  14. ↑ "Science Diplomacy and Leadership Workshop Trains Next Generation of Leaders and Advocates". AAAS - The World's Largest General Scientific Society. 2017-11-10. Retrieved 2018-06-17.
  15. ↑ Holford, Mande; Dalton, Gordon; Acevedo-Rocha, Carlos (2013-12-03). "Young Scientists and Social Innovators Making Science Sustainable for the Next Generation". doi:10.6084/m9.figshare.866820.
  16. ↑ Oni, Mandë Holford,Tolu. "Diplomacy for Scientists". Scientific American Blog Network. Retrieved 2018-06-17.
  17. ↑ Holford, Mandë; Nichols, Rodney (2015-07-31). "A tale of two states". Science. 349 (6247): 455–455. doi:10.1126/science.aaa9595. ISSN 0036-8075. PMID 26228115.
  18. ↑ "Membership Roster". Council on Foreign Relations. Retrieved 2018-06-17.
  19. ↑ "NSF Award Search: Award#1445413 - I-Corps: Killer Snail: An interactive marine biodiversity learning tool". nsf.gov. Retrieved 2018-06-17.
  20. ↑ "KILLER SNAILS LLC | SBIR.gov". www.sbir.gov. Retrieved 2018-06-17.
  21. ↑ "April 30, 2018 – Serious Play Conference". seriousplayconf.com. Retrieved 2018-06-17.
  22. ↑ World Science Festival (2016-05-11), The Moth - Mandë Holford: It's All Relative, retrieved 2018-06-17
  23. ↑ "NBC Learn". NBC Learn. Retrieved 2018-06-17.
  24. ↑ "Mandë Holford - Science Friday". Science Friday. Retrieved 2018-06-17.
  25. ↑ Killer Snails, retrieved 2018-06-17
  26. ↑ "NSF Award Search: Award#1247550 - CAREER: Development of a teretoxin neuropeptide array for investigating neuronal circuits". www.nsf.gov. Retrieved 2018-06-17.
  27. ↑ "Young Scientists". World Economic Forum. Retrieved 2018-06-17.
  28. ↑ "Mande Holford Wins Camille Dreyfus Teacher-Scholar Award". www.gc.cuny.edu. Retrieved 2018-06-17.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.