Macrophage-capping protein

CAPG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J72, 1JHW
Identifiers
Aliases	CAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDs	MGI: 1098259 HomoloGene: 37523 GeneCards: CAPG
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	85,418,432 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	72,562,983 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein complex binding; • actin binding; • protein binding; • protein domain specific binding; • cadherin binding; • actin filament binding;
Cellular component	• cytoplasm; • F-actin capping protein complex; • melanosome; • centriole; • mitotic spindle; • nucleolus; • extracellular exosome; • cell nucleus; • Flemming body; • nucleoplasm; • extracellular region;
Biological process	• barbed-end actin filament capping; • extracellular matrix disassembly; • positive regulation of podosome assembly; • actin filament capping; • protein complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	822
	12332
	ENSG00000042493
	ENSMUSG00000056737
	P40121
	P24452
NM_001256139; NM_001256140; NM_001747; NM_001320732; NM_001320733;
	NM_001320734
	NM_001042534; NM_001271395; NM_001271415; NM_007599
NP_001243068; NP_001243069; NP_001307661; NP_001307662; NP_001307663;
	NP_001738
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.^[5]^[6]^[7]

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.^[8] The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. PMID 1322908.
↑ Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.
1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
↑ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.

Southwick FS (1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G". J. Biol. Chem. 270 (1): 45–8. doi:10.1074/jbc.270.1.45. PMID 7814409.
Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location". Genomics. 23 (3): 560–5. doi:10.1006/geno.1994.1543. PMID 7851883.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell. 89 (4): 511–21. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743.
Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H". Mol. Biol. Cell. 12 (11): 3527–37. doi:10.1091/mbc.12.11.3527. PMC 60273. PMID 11694586.
Van Impe K, De Corte V, Eichinger L, et al. (2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". J. Biol. Chem. 278 (20): 17945–52. doi:10.1074/jbc.M209946200. PMID 12637565.
De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion". J. Cell Sci. 117 (Pt 22): 5283–92. doi:10.1242/jcs.01410. PMID 15454578.
Watari A, Takaki K, Higashiyama S, et al. (2007). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–80. doi:10.1038/sj.onc.1209732. PMID 16767159.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid1322908-5] Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. PMID 1322908.

[pmid12754261-6] Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.

[entrez-7] 1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".

[8] Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.

Macrophage-capping protein

Function

References

Further reading