MYOZ1

MYOZ1
Identifiers
AliasesMYOZ1, CS-2, FATZ, MYOZ, myozenin 1
External IDsMGI: 1929471 HomoloGene: 23311 GeneCards: MYOZ1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q22.2Start73,631,654 bp[1]
End73,641,757 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

58529

59011

Ensembl

ENSG00000177791

ENSMUSG00000068697

UniProt

Q9NP98

Q9JK37

RefSeq (mRNA)

NM_021245

NM_021508

RefSeq (protein)

NP_067068

NP_067483

Location (UCSC)Chr 10: 73.63 – 73.64 MbChr 14: 20.65 – 20.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myozenin-1 is a protein that in humans is encoded by the MYOZ1 gene.[5][6][7]

Interactions

MYOZ1 has been shown to interact with Telethonin,[6][8] FLNC[5][6][8] and Actinin, alpha 2.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000177791 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068697 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Takada F, Vander Woude DL, Tong HQ, Thompson TG, Watkins SC, Kunkel LM, Beggs AH (Feb 2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proc Natl Acad Sci USA. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMC 29302. PMID 11171996.
  6. 1 2 3 4 Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic' S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G (Jan 2001). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J Biol Chem. 275 (52): 41234–42. doi:10.1074/jbc.M007493200. PMID 10984498.
  7. ↑ "Entrez Gene: MYOZ1 myozenin 1".
  8. 1 2 Frey, Norbert; Olson Eric N (Apr 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. United States. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. ISSN 0021-9258. PMID 11842093.

Further reading

  • Faulkner G, Pallavicini A, Formentin E, et al. (1999). "ZASP: a new Z-band alternatively spliced PDZ-motif protein". J. Cell Biol. 146 (2): 465–75. doi:10.1083/jcb.146.2.465. PMC 3206570. PMID 10427098.
  • Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
  • Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gontier Y, Taivainen A, Fontao L, et al. (2006). "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins". J. Cell Sci. 118 (Pt 16): 3739–49. doi:10.1242/jcs.02484. PMID 16076904.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Arola AM, Sanchez X, Murphy RT, et al. (2007). "Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy". Mol. Genet. Metab. 90 (4): 435–40. doi:10.1016/j.ymgme.2006.12.008. PMID 17254821.
  • Posch MG, Perrot A, Dietz R, et al. (2007). "Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy". Mol. Genet. Metab. 91 (2): 207–8. doi:10.1016/j.ymgme.2007.02.014. PMID 17434779.


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