MTIF2

MTIF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMTIF2, mitochondrial translational initiation factor 2
External IDsMGI: 1924034 HomoloGene: 1840 GeneCards: MTIF2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p16.1Start55,236,595 bp[1]
End55,269,347 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4528

76784

Ensembl

ENSG00000085760

ENSMUSG00000020459

UniProt

P46199
Q6P1N2

Q91YJ5

RefSeq (mRNA)

NM_001282118
NM_001282119
NM_001282120
NM_133767

RefSeq (protein)

NP_001269047
NP_001269048
NP_001269049
NP_598528

Location (UCSC)Chr 2: 55.24 – 55.27 MbChr 11: 29.53 – 29.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[5][6][7]

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000085760 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020459 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935.
  6. ↑ Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
  7. 1 2 "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Overman RG, Enderle PJ, Farrow JM, et al. (2003). "The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene". Biochim. Biophys. Acta. 1628 (3): 195–205. doi:10.1016/s0167-4781(03)00144-1. PMID 12932832.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
  • Miura E, Kato Y, Matsushima R, et al. (2007). "The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants". Plant Cell. 19 (4): 1313–28. doi:10.1105/tpc.106.049270. PMC 1913758. PMID 17416734.


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