STK3

STK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WWS, 4HKD, 4L0N, 4LG4, 4LGD, 4OH9, 5BRM
Identifiers
Aliases	STK3, KRS1, MST2, serine/threonine kinase 3
External IDs	MGI: 1928487 HomoloGene: 48420 GeneCards: STK3
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	98,942,827 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	35,178,921 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • nucleotide binding; • protein dimerization activity; • protein serine/threonine kinase activator activity; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • protein binding; • ATP binding; • magnesium ion binding; • protein kinase activity; • identical protein binding;
Cellular component	• cytoplasm; • cytosol; • cell nucleus; • macromolecular complex;
Biological process	• regulation of cell differentiation involved in embryonic placenta development; • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; • positive regulation of protein kinase B signaling; • intracellular signal transduction; • phosphorylation; • protein stabilization; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of JNK cascade; • hippo signaling; • endocardium development; • protein phosphorylation; • primitive hemopoiesis; • central nervous system development; • positive regulation of apoptotic process; • positive regulation of protein binding; • cell differentiation involved in embryonic placenta development; • positive regulation of fat cell differentiation; • negative regulation of organ growth; • neural tube formation; • negative regulation of canonical Wnt signaling pathway; • signal transduction; • negative regulation of cell proliferation; • hepatocyte apoptotic process; • apoptotic process; • positive regulation of protein serine/threonine kinase activity; • regulation of mitotic cell cycle; • signal transduction by protein phosphorylation; • stress-activated protein kinase signaling cascade; • regulation of apoptotic process; • activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	6788
	56274
	ENSG00000104375
	ENSMUSG00000022329
	Q13188
	Q9JI10
	NM_001256312; NM_001256313; NM_006281
	NM_019635; NM_001357821
	NP_001243241; NP_001243242; NP_006272
	NP_062609; NP_001344750
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.^[5]^[6]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104375 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022329 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Taylor LK, Wang HC, Erikson RL (Nov 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc Natl Acad Sci U S A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.
1 2 "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

Creasy CL, Chernoff J (1995). "Cloning and characterization of a human protein kinase with homology to Ste20". J. Biol. Chem. 270 (37): 21695–700. doi:10.1074/jbc.270.37.21695. PMID 7665586.
Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
Creasy CL, Chernoff J (1996). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases". Gene. 167 (1–2): 303–6. doi:10.1016/0378-1119(95)00653-2. PMID 8566796.
Bren A, Welch M, Blat Y, Eisenbach M (1996). "Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10090–3. doi:10.1073/pnas.93.19.10090. PMC 38341. PMID 8816756.
Wang HC, Fecteau KA (2000). "Detection of a novel quiescence-dependent protein kinase". J. Biol. Chem. 275 (33): 25850–7. doi:10.1074/jbc.M000818200. PMID 10840030.
Lee KK, Ohyama T, Yajima N, et al. (2001). "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation". J. Biol. Chem. 276 (22): 19276–85. doi:10.1074/jbc.M005109200. PMID 11278283.
De Souza PM, Kankaanranta H, Michael A, et al. (2002). "Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis". Blood. 99 (9): 3432–8. doi:10.1182/blood.V99.9.3432. PMID 11964314.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deng Y, Pang A, Wang JH (2003). "Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis". J. Biol. Chem. 278 (14): 11760–7. doi:10.1074/jbc.M211085200. PMID 12554736.
Rabizadeh S, Xavier RJ, Ishiguro K, et al. (2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
O'Neill E, Rushworth L, Baccarini M, Kolch W (2005). "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1". Science. 306 (5705): 2267–70. doi:10.1126/science.1103233. PMID 15618521.
Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.
Oh HJ, Lee KK, Song SJ, et al. (2006). "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis". Cancer Res. 66 (5): 2562–9. doi:10.1158/0008-5472.CAN-05-2951. PMID 16510573.
Callus BA, Verhagen AM, Vaux DL (2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation". FEBS J. 273 (18): 4264–76. doi:10.1111/j.1742-4658.2006.05427.x. PMID 16930133.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Seidel C, Schagdarsurengin U, Blümke K, et al. (2007). "Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma". Mol. Carcinog. 46 (10): 865–71. doi:10.1002/mc.20317. PMID 17538946.
Matallanas D, Romano D, Yee K, et al. (2007). "RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein". Mol. Cell. 27 (6): 962–75. doi:10.1016/j.molcel.2007.08.008. PMC 2821687. PMID 17889669.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104375 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022329 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8816758-5] Taylor LK, Wang HC, Erikson RL (Nov 1996). "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2". Proc Natl Acad Sci U S A. 93 (19): 10099–104. doi:10.1073/pnas.93.19.10099. PMC 38343. PMID 8816758.

[entrez-6] 1 2 "Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)".

Signaling pathway: Hippo signaling pathway
Receptor	FAT4
Adaptor protein	NF2 FRMD6 SAV1 MOBKL1A MOBKL1B
Kinase	MST1 LATS1 LATS2 STK3
Transcription factor	YAP1 TAZ
Other/unknown	RASSF1

STK3

References

Further reading