MOBKL1A

MOB1B
Identifiers
AliasesMOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B
External IDsMGI: 1915723 HomoloGene: 61676 GeneCards: MOB1B
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q13.3Start70,902,326 bp[1]
End71,022,449 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

92597

68473

Ensembl

ENSG00000173542

ENSMUSG00000006262

UniProt

Q7L9L4

Q8BPB0

RefSeq (mRNA)

NM_001244766
NM_001244767
NM_173468

NM_026735

RefSeq (protein)

NP_001231695
NP_001231696
NP_775739

NP_081011

Location (UCSC)Chr 4: 70.9 – 71.02 MbChr 5: 88.72 – 88.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.[5][6]

Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.[5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000173542 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006262 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: MOB1".
  6. ↑ Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi:10.1002/ijc.24878. PMID 19739119.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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