MPP5

MPP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMPP5, PALS1, membrane palmitoylated protein 5
External IDsMGI: 1927339 HomoloGene: 9512 GeneCards: MPP5
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q23.3Start67,241,109 bp[1]
End67,335,819 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64398

56217

Ensembl

ENSG00000072415

ENSMUSG00000021112

UniProt

Q8N3R9

Q9JLB2

RefSeq (mRNA)

NM_001256550
NM_022474

NM_019579

RefSeq (protein)

NP_001243479
NP_071919

NP_062525

Location (UCSC)Chr 14: 67.24 – 67.34 MbChr 12: 78.75 – 78.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.[5][6]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM][6]

Interactions

MPP5 has been shown to interact with INADL and FAM71D.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000072415 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021112 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
  6. 1 2 "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7". J. Biol. Chem. 275 (15): 11425–31. doi:10.1074/jbc.275.15.11425. PMID 10753959.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain". Biochim. Biophys. Acta. 1518 (3): 249–59. doi:10.1016/s0167-4781(01)00191-9. PMID 11311936.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Makarova O, Roh MH, Liu CJ, et al. (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
  • Hurd TW, Gao L, Roh MH, et al. (2003). "Direct interaction of two polarity complexes implicated in epithelial tight junction assembly". Nat. Cell Biol. 5 (2): 137–42. doi:10.1038/ncb923. PMID 12545177.
  • Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Penkert RR, DiVittorio HM, Prehoda KE (2004). "Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex". Nat. Struct. Mol. Biol. 11 (11): 1122–7. doi:10.1038/nsmb839. PMC 2140275. PMID 15475968.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Stöhr H, Molday LL, Molday RS, et al. (2005). "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina". J. Comp. Neurol. 481 (1): 31–41. doi:10.1002/cne.20367. PMID 15558731.
  • Feng W, Long JF, Zhang M (2005). "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (19): 6861–6. doi:10.1073/pnas.0409346102. PMC 1100767. PMID 15863617.
  • Kantardzhieva A, Gosens I, Alexeeva S, et al. (2005). "MPP5 recruits MPP4 to the CRB1 complex in photoreceptors". Invest. Ophthalmol. Vis. Sci. 46 (6): 2192–201. doi:10.1167/iovs.04-1417. PMID 15914641.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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