MOGAT2

MOGAT2
Identifiers
Aliases	MOGAT2, DGAT2L5, MGAT2, DGAT2L5., hDC5, monoacylglycerol O-acyltransferase 2
External IDs	MGI: 2663253 HomoloGene: 57020 GeneCards: MOGAT2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	75,732,958 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	99,238,619 bp[2]
Gene ontology
Molecular function	• transferase activity; • acetyltransferase activity; • transferase activity, transferring acyl groups; • transferase activity, transferring acyl groups other than amino-acyl groups; • 2-acylglycerol O-acyltransferase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum; • membrane; • endoplasmic reticulum membrane;
Biological process	• intestinal absorption; • glycerol metabolic process; • diacylglycerol biosynthetic process; • lipid metabolic process; • triglyceride biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	80168
	233549
	ENSG00000166391
	ENSMUSG00000052396
	Q3SYC2
	Q80W94
	NM_025098
	NM_177448
	NP_079374
	NP_803231
	Wikidata
View/Edit Human	View/Edit Mouse

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.

MOGAT2 and the related MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG) from monoacylglycerol (MAG).

MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in ruminants both genes have undergone tandem gene expansion, indicate of evolving functionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166391 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052396 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677.
↑ "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".
↑ Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.

Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y (Apr 2004). "A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet". The Journal of Biological Chemistry. 279 (18): 18878–86. doi:10.1074/jbc.M313272200. PMID 14966132.
Lockwood JF, Cao J, Burn P, Shi Y (Nov 2003). "Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity". American Journal of Physiology. Endocrinology and Metabolism. 285 (5): E927–37. doi:10.1152/ajpendo.00179.2003. PMID 12824082.
Yen CL, Farese RV (May 2003). "MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine". The Journal of Biological Chemistry. 278 (20): 18532–7. doi:10.1074/jbc.M301633200. PMID 12621063.
Cao J, Lockwood J, Burn P, Shi Y (Apr 2003). "Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2". The Journal of Biological Chemistry. 278 (16): 13860–6. doi:10.1074/jbc.M300139200. PMID 12576479.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166391 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052396 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid14970677-5] Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677.

[entrez-6] "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".

[The_Sheep_Genome-7] Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.

MOGAT2

References

Further reading