MicroRNA 494 is a microRNA that in humans is encoded by the MIR494 gene.[2]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. This RefSeq represents the predicted microRNA stem-loop.[2]
Further reading
- Diakos C, Zhong S, Xiao Y, Zhou M, Vasconcelos GM, Krapf G, Yeh RF, Zheng S, Kang M, Wiencke JK, Pombo-de-Oliveira MS, Panzer-Grümayer R, Wiemels JL (December 2010). "TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a". Blood. 116 (23): 4885–93. doi:10.1182/blood-2009-02-206706. PMC 3265147. PMID 20807887.
- Olaru AV, Ghiaur G, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM (December 2011). "MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint". Hepatology. 54 (6): 2089–98. doi:10.1002/hep.24591. PMC 3212606. PMID 21809359.
- Tominaga K, Srikantan S, Lee EK, Subaran SS, Martindale JL, Abdelmohsen K, Gorospe M (October 2011). "Competitive regulation of nucleolin expression by HuR and miR-494". Molecular and Cellular Biology. 31 (20): 4219–31. doi:10.1128/MCB.05955-11. PMC 3187287. PMID 21859890.
- Megiorni F, Cialfi S, Dominici C, Quattrucci S, Pizzuti A (2011). "Synergistic post-transcriptional regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 specific binding". PLOS One. 6 (10): e26601. doi:10.1371/journal.pone.0026601. PMC 3197680. PMID 22028919.
- Kim WK, Park M, Kim YK, Tae YK, Yang HK, Lee JM, Kim H (December 2011). "MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation". Clinical Cancer Research. 17 (24): 7584–94. doi:10.1158/1078-0432.CCR-11-0166. PMID 22042971.
- Ohdaira H, Sekiguchi M, Miyata K, Yoshida K (February 2012). "MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells". Cell Proliferation. 45 (1): 32–8. doi:10.1111/j.1365-2184.2011.00798.x. PMID 22151897.
- Yamanaka S, Campbell NR, An F, Kuo SC, Potter JJ, Mezey E, Maitra A, Selaru FM (July 2012). "Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma". Cell Cycle. 11 (14): 2729–38. doi:10.4161/cc.21105. PMC 3409013. PMID 22785131.
- Altmäe S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, Salumets A (March 2013). "MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity". Reproductive Sciences. 20 (3): 308–17. doi:10.1177/1933719112453507. PMC 4077381. PMID 22902743.
- Romano G, Acunzo M, Garofalo M, Di Leva G, Cascione L, Zanca C, Bolon B, Condorelli G, Croce CM (October 2012). "MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16570–5. doi:10.1073/pnas.1207917109. PMC 3478630. PMID 23012423.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.