MIB2 (gene)

MIB2
Identifiers
Aliases	MIB2, ZZANK1, ZZZ5, mindbomb E3 ubiquitin protein ligase 2
External IDs	MGI: 2679684 HomoloGene: 16062 GeneCards: MIB2
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	1,630,610 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	155,669,198 bp[2]
Gene ontology
Molecular function	• signal transducer activity; • zinc ion binding; • ubiquitin protein ligase activity; • metal ion binding; • actin binding; • protein binding; • ubiquitin-protein transferase activity; • transferase activity;
Cellular component	• cytoplasm; • endosome; • early endosome; • ubiquitin ligase complex; • cytosol;
Biological process	• Notch signaling pathway; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • protein ubiquitination; • protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	142678
	76580
	ENSG00000197530
	ENSMUSG00000029060
	Q96AX9
	Q8R516
	NM_001170686; NM_001170687; NM_001170688; NM_001170689; NM_080875
	NM_001256107; NM_001256108; NM_001256110; NM_145124
	NP_001164157; NP_001164158; NP_001164159; NP_001164160; NP_543151
	NP_001243036; NP_001243037; NP_660106
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase MIB2 is an enzyme that in humans is encoded by the MIB2 gene.^[5]^[6]

Interactions

MIB2 (gene) has been shown to interact with Actin, alpha 1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
↑ "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".
↑ Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeuchi T, Heng HH, Ye CJ, et al. (2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. PMC 1868282. PMID 14507647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Koo BK, Yoon KJ, Yoo KW, et al. (2005). "Mind bomb-2 is an E3 ligase for Notch ligand". J. Biol. Chem. 280 (23): 22335–42. doi:10.1074/jbc.M501631200. PMID 15824097.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma". DNA Cell Biol. 24 (5): 339–44. doi:10.1089/dna.2005.24.339. PMID 15869411.
Takeuchi T, Adachi Y, Ohtsuki Y (2005). "Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma". Am. J. Pathol. 166 (6): 1817–26. doi:10.1016/S0002-9440(10)62491-1. PMC 1602431. PMID 15920166.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Takeuchi T, Adachi Y, Sonobe H, et al. (2006). "A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion". Oncogene. 25 (53): 7059–69. doi:10.1038/sj.onc.1209688. PMID 16715130.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197530 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029060 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12761501-5] Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

[entrez-6] "Entrez Gene: MIB2 mindbomb homolog 2 (Drosophila)".

[pmid14507647-7] Takeuchi, Tamotsu; Heng Henry H Q; Ye Christine J; Liang Sheng-Ben; Iwata Jun; Sonobe Hiroshi; Ohtsuki Yuji (Oct 2003). "Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma". Am. J. Pathol. United States. 163 (4): 1395–404. doi:10.1016/S0002-9440(10)63497-9. ISSN 0002-9440. PMC 1868282. PMID 14507647.

MIB2 (gene)

Interactions

References

Further reading