METTL14

METTL14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IL1, 5K7W, 5IL2, 5IL0, 5K7M, 5K7U
Identifiers
Aliases	METTL14, methyltransferase like 14, hMETTL14
External IDs	MGI: 2442926 HomoloGene: 10865 GeneCards: METTL14
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	118,715,433 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	123,386,108 bp[2]
Gene ontology
Molecular function	• RNA binding; • mRNA binding; • S-adenosyl-L-methionine binding; • protein binding; • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity;
Cellular component	• RNA N6-methyladenosine methyltransferase complex; • cell nucleus; • nucleoplasm;
Biological process	• stem cell population maintenance; • mRNA splicing, via spliceosome; • mRNA destabilization; • mRNA methylation; • RNA methylation; • mRNA catabolic process; • spermatogenesis; • forebrain radial glial cell differentiation; • gliogenesis; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	57721
	210529
	ENSG00000145388
	ENSMUSG00000028114
	Q9HCE5
	Q3UIK4
	NM_020961
	NM_201638
	NP_066012
	NP_964000
	Wikidata
View/Edit Human	View/Edit Mouse

Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene. ^[5]

References

Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (June 2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C (February 2014). "A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation". Nat. Chem. Biol. 10 (2): 93–5. doi:10.1038/nchembio.1432. PMC 3911877. PMID 24316715.
Wang X, Feng J, Xue Y, Guan Z, Zhang D, Liu Z, Gong Z, Wang Q, Huang J, Tang C, Zou T, Yin P (June 2016). "Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex". Nature. 534 (7608): 575–8. doi:10.1038/nature18298. PMID 27281194.
Śledź P, Jinek M (September 2016). "Structural insights into the molecular mechanism of the m(6)A writer complex". eLife. 5. doi:10.7554/eLife.18434. PMC 5023411. PMID 27627798.

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