METTL1

METTL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMETTL1, C12orf1, TRM8, TRMT8, YDL201w, methyltransferase like 1
External IDsMGI: 1339986 HomoloGene: 3918 GeneCards: METTL1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q14.1Start57,768,471 bp[1]
End57,772,793 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4234

17299

Ensembl

ENSG00000037897

ENSMUSG00000006732

UniProt

Q9UBP6

Q9Z120

RefSeq (mRNA)

NM_005371
NM_023032
NM_023033

NM_010792

RefSeq (protein)

NP_005362
NP_075422

NP_034922

Location (UCSC)Chr 12: 57.77 – 57.77 MbChr 10: 127.04 – 127.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA (guanine-N(7)-)-methyltransferase is an enzyme that in humans is encoded by the METTL1 gene.[5][6]

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphylation. Alternative splice variants encoding different protein isoforms and transcript variants utilizing alternative polyA sites have been described in the literature.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000037897 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006732 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Bahr A, Hankeln T, Fiedler T, Hegemann J, Schmidt ER (Aug 1999). "Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation". Genomics. 57 (3): 424–8. doi:10.1006/geno.1999.5780. PMID 10329009.
  6. 1 2 "Entrez Gene: METTL1 methyltransferase like 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Alexandrov A, Martzen MR, Phizicky EM (2002). "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA". RNA. 8 (10): 1253–66. doi:10.1017/S1355838202024019. PMC 1370335. PMID 12403464.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Cartlidge RA, Knebel A, Peggie M, et al. (2005). "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells". EMBO J. 24 (9): 1696–705. doi:10.1038/sj.emboj.7600648. PMC 1142581. PMID 15861136.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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