MED12L

MED12L
Identifiers
Aliases	MED12L, NOPAR, TNRC11L, TRALP, TRALPUSH, mediator complex subunit 12 like
External IDs	MGI: 2139916 HomoloGene: 43143 GeneCards: MED12L
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	151,437,072 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	59,318,682 bp[2]
Gene ontology
Molecular function	• RNA polymerase II transcription coactivator activity; • beta-catenin binding; • RNA polymerase II transcription cofactor activity; • transcription cofactor activity; • transcription coactivator activity;
Cellular component	• cell nucleus; • mediator complex;
Biological process	• regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of transcription from RNA polymerase II promoter; • regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	116931
	329650
	ENSG00000144893
	ENSMUSG00000056476
	Q86YW9
	Q8BQM9
	NM_053002
	NM_177855
	NP_443728
	NP_808523
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator complex subunit 12 like (Med12L) is a protein that in humans is encoded by the MED12L gene. ^[5]

Function

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000144893 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056476 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Mediator complex subunit 12 like". Retrieved 2018-02-06.

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000144893 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056476 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: Mediator complex subunit 12 like". Retrieved 2018-02-06.

MED12L

Function

See also

References

Further reading