MDFI

MDFI
Identifiers
AliasesMDFI, MyoD family inhibitor, I-MF, I-mfa
External IDsMGI: 107687 HomoloGene: 21150 GeneCards: MDFI
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.1Start41,636,882 bp[1]
End41,654,246 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4188

17240

Ensembl

ENSG00000112559

ENSMUSG00000032717

UniProt

Q99750

P70331

RefSeq (mRNA)

NM_001300804
NM_001300805
NM_001300806
NM_005586

NM_001109973
NM_001276390
NM_001276391
NM_010783

RefSeq (protein)

NP_001287733
NP_001287734
NP_001287735
NP_005577

NP_001103443
NP_001263319
NP_001263320
NP_034913

Location (UCSC)Chr 6: 41.64 – 41.65 MbChr 17: 47.82 – 47.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MyoD family inhibitor is a protein that in humans is encoded by the MDFI gene.[5][6][7]

Function

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.[7]

Interactions

MDFI has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000112559 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032717 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Kraut N (Sep 1997). "The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and mouse chromosome 17". Mamm Genome. 8 (8): 618–9. doi:10.1007/s003359900517. PMID 9250874.
  6. ↑ Wang Q, Young TM, Mathews MB, Pe'ery T (Mar 2007). "Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription". J Mol Biol. 367 (3): 630–46. doi:10.1016/j.jmb.2007.01.020. PMC 1868487. PMID 17289077.
  7. 1 2 "Entrez Gene: MDFI MyoD family inhibitor".
  8. 1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  9. 1 2 Chen CM, Kraut N, Groudine M, Weintraub H (Sep 1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/s0092-8674(00)80148-8. PMID 8797820.

Further reading

  • Chen CM, Kraut N, Groudine M, Weintraub H (1996). "I-mf, a novel myogenic repressor, interacts with members of the MyoD family". Cell. 86 (5): 731–41. doi:10.1016/S0092-8674(00)80148-8. PMID 8797820.
  • Kraut N, Snider L, Chen CM, Tapscott SJ, Groudine M (1999). "Requirement of the mouse I-mfa gene for placental development and skeletal patterning". EMBO J. 17 (21): 6276–88. doi:10.1093/emboj/17.21.6276. PMC 1170953. PMID 9799236.
  • Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ (2001). "Inhibition of Tcf3 binding by I-mfa domain proteins". Mol. Cell. Biol. 21 (5): 1866–73. doi:10.1128/MCB.21.5.1866-1873.2001. PMC 86756. PMID 11238923.
  • Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L (2004). "Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1". J. Biol. Chem. 278 (52): 52763–72. doi:10.1074/jbc.M309610200. PMID 14530267.
  • Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K, Aruga J (2004). "Myogenic repressor I-mfa interferes with the function of Zic family proteins". Biochem. Biophys. Res. Commun. 320 (1): 233–40. doi:10.1016/j.bbrc.2004.05.158. PMID 15207726.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.


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