Lisa Jones (scientist)

Lisa Jones
Alma mater

Syracuse University

Georgia State University
Known for Cell footprinting
Scientific career
Institutions

University of Maryland
Indiana University-Purdue University Indianapolis

Washington University

Lisa M. Jones is an Assistant Professor of Pharmaceutical Sciences at the University of Maryland, Baltimore.

Early life and education

Jones became interested in science as a freshman at high school, where she took part in a national Science Technology Engineering Program.[1] She went to college at Syracuse University, where she was the only person of colour.[2] Jones completed her PhD at Georgia State University and specialized in structural biology.[3]

Research and career

She was a Pfizer postdoctoral researcher at Washington University in St. Louis.[4][1] She joined Indiana University – Purdue University Indianapolis, where she became an Associate Professor.[5][6] In 2016 Jones won a $1.1 million National Science Foundation Career grant to develop new techniques to study cell membranes.[1] Her award supported research training for students from historically black colleges and universities to work in biochemistry.[1] She developed cell-footprinting, a technique that uses mass spectrometry coupled with in vivo fast photochemical oxidation of proteins (FPOP).[1][7][8] She is recognised as developing solving new questions in medicine as well as tools for biomedical researchers.[6]

She moved to the University of Maryland School of Pharmacy in 2016.[9] The Jones Lab is a structural proteomics group, who specialist in FPOP using an excimer laser for photolysis, which generates hydroxyl radicals.[10] Hydroxyl radicals go on to oxidise the side chains of amino acids and provide solvent accessibility of proteins within a cell.[11] FPOP can provide information on the sites of ligand binding, protein interaction and protein conformational changes.[10]

References

  1. 1 2 3 4 5 "IUPUI chemist receives $1.1M NSF grant for research, training of minority future researchers: Newscenter: Indiana University–Purdue University Indianapolis". archive.news.iupui.edu. Retrieved 2018-04-22.
  2. ↑ @Victoria08Davis, VICTORIA T. DAVIS. "IUPUI chemist awarded more than $1 million for research, training of minority students". Indianapolis Recorder Newspaper. Retrieved 2018-04-22.
  3. ↑ Chea, Emily E.; Jones, Lisa M. (2018-02-12). "Analyzing the structure of macromolecules in their native cellular environment using hydroxyl radical footprinting". Analyst. 143 (4). doi:10.1039/C7AN01323J. ISSN 1364-5528.
  4. ↑ Jones, Lisa M.; Zhang, Hao; Vidavsky, Ilan; Gross, Michael L. (2010-02-15). "An On-Line, High-Pressure Digestion System for Protein Characterization by Hydrogen/Deuterium Exchange and Mass Spectrometry". Analytical Chemistry. 82 (4): 1171–1174. doi:10.1021/ac902477u. PMC 2826105. PMID 20095571.
  5. ↑ "Lisa Jones". stem.indiana.edu. Retrieved 2018-04-22.
  6. 1 2 Brown, Alex. "IUPUI Professor Receives Lucrative Award". Retrieved 2018-04-22.
  7. ↑ "NSF Award Search: Award#1701692 - CAREER: Development of an In Cell Footprinting Method for the Analysis of Protein Structure". www.nsf.gov. Retrieved 2018-04-22.
  8. ↑ Rinas, Aimee; Mali, Vishaal S.; Espino, Jessica A.; Jones, Lisa M. (2016-10-07). "Development of a Microflow System for In-Cell Footprinting Coupled with Mass Spectrometry". Analytical Chemistry. 88 (20): 10052–10058. doi:10.1021/acs.analchem.6b02357.
  9. ↑ "Its official! We're getting FPOP in Baltimore!". proteomicsnews.blogspot.co.uk. Retrieved 2018-04-22.
  10. 1 2 "Lisa Jones". faculty.rx.umaryland.edu. Retrieved 2018-04-22.
  11. ↑ "Professor Lisa Jones - Indiana University" (PDF). University of Toledo. 2014-09-24. Retrieved 2018-04-22.
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