Lim homeobox 9

LHX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMQ
Identifiers
Aliases	LHX9, LIM homeobox 9
External IDs	MGI: 1316721 HomoloGene: 7816 GeneCards: LHX9
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.3 Start 197,911,902 bp[1] End 197,935,478 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 138,825,186 bp[2] End 138,848,577 bp[2]
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • protein binding • transcription corepressor activity • metal ion binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cell nucleus Biological process • cell proliferation • male gonad development • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • female gonad development • gonad morphogenesis • dorsal spinal cord interneuron anterior axon guidance • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56956	16876
Ensembl	ENSG00000143355	ENSMUSG00000019230
UniProt	Q9NQ69	Q9WUH2
RefSeq (mRNA)	NM_001014434 NM_020204	NM_001025565 NM_001042577 NM_010714
RefSeq (protein)	NP_001014434 NP_064589	NP_001020736 NP_001036042 NP_034844
Location (UCSC)	Chr 1: 197.91 – 197.94 Mb	Chr 1: 138.83 – 138.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

LIM homeobox 9 is a protein that in humans is encoded by the LHX9 gene.^[5]

Function

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants.

References

Further reading

• Avraham O, Hadas Y, Vald L, Zisman S, Schejter A, Visel A, Klar A (2009). "Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1". Neural Dev. 4: 21. doi:10.1186/1749-8104-4-21. PMC 2704203. PMID 19545367.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.