Levomoramide
| |
Clinical data | |
---|---|
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ECHA InfoCard |
100.024.658 |
Chemical and physical data | |
Formula | C25H32N2O2 |
Molar mass | 392.534 |
3D model (JSmol) | |
| |
| |
|
Levomoramide is the inactive isomer of the opioid analgesic dextromoramide, invented by the chemist Paul Janssen in 1956. Unlike dextromoramide, which is a potent analgesic with high abuse potential, levomoramide is virtually without activity.[1][2]
"Resolution reveals that the analgetic activity in this case resides almost entirely in the (+) isomer."[3]
"In the α-CH3 series, one of the optical isomers of each enantiomorphic pair is about twice as active as the racemic mixture; the other isomer is devoid of significant analgesic activity."[4]
However, despite being inactive, levomoramide is scheduled by UN Single Convention on Narcotic Drugs.
References
- ↑ Janssen PA. Journal of the American Chemical Society. 1956;78:3862.
- ↑ Janssen PA, Jagenau AM. Journal of Pharmacy and Pharmacology 1957;9:381.
- ↑ Daniel Lednicer. Central Analgetics. (1982), p194. ISBN 0-471-08314-3
- ↑ Paul A J Janssen. Synthetic Analgesics Part 1: Diphenylpropylamines. Pergamon Press 1960. p143.
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.