Lethal synthesis

Lethal synthesis, or suicide metabolism,[1] is the biosynthesis of a toxin from a precursor which is not itself toxic, such as the synthesis of fluorocitrate from fluoroacetate.[2][3]

The term was first publicised by Rudolph Peters in his Croonian Lecture of 1951.[4][3][5]

References

  1. ↑ "Lethal synthesis". Compendium of Chemical Terminology (the "Gold Book"). IUPAC. Retrieved 2018-03-13.
  2. ↑ "Lethal synthesis". Oxford Reference. Oxford University Press. Retrieved 2018-03-12.
  3. 1 2 van der Kamp, Marc W.; McGeagh, John D.; Mulholland, Adrian J. (24 October 2011). ""Lethal Synthesis" of Fluorocitrate by Citrate Synthase Explained through QM/MM Modeling". Angewandte Chemie International Edition. 50 (44): 10349–10351. doi:10.1002/anie.201103260.
  4. ↑ Peters, R. A. (28 February 1952). "Croonian Lecture: Lethal Synthesis". Proceedings of the Royal Society B: Biological Sciences. 139 (895): 143–170. doi:10.1098/rspb.1952.0001.
  5. ↑ Anon (1982). "Obituary". BMJ. 284 (6315): 589. doi:10.1136/bmj.284.6315.589.


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