Left-right determination factor 1

LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	MGI: 107405 HomoloGene: 49231 GeneCards: LEFTY1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	225,911,382 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	180,938,400 bp[2]
Gene ontology
Molecular function	• transforming growth factor beta receptor binding; • cytokine activity; • growth factor activity;
Cellular component	• extracellular region; • extracellular space;
Biological process	• regulation of apoptotic process; • multicellular organism development; • positive regulation of pathway-restricted SMAD protein phosphorylation; • heart morphogenesis; • determination of left/right symmetry; • negative regulation of transcription from RNA polymerase II promoter; • transforming growth factor beta receptor signaling pathway; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • BMP signaling pathway; • regulation of receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10637
	13590
	ENSG00000243709
	ENSMUSG00000038793
	O75610
	Q64280
	NM_020997
	NM_010094
	NP_066277
	NP_034224
	Wikidata
View/Edit Human	View/Edit Mouse

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene. ^[5]

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000243709 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038793 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Left-right determination factor 1". Retrieved 2016-08-03.

Left-right determination factor 1

Function

References

Further reading