LSM3

LSM3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM3, SMX4, USS2, YLR438C, LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDsMGI: 1914928 HomoloGene: 6548 GeneCards: LSM3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p25.1Start14,178,358 bp[1]
End14,201,119 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27258

67678

Ensembl

ENSG00000170860

ENSMUSG00000034192

UniProt

P62310

P62311

RefSeq (mRNA)

NM_014463

NM_026309

RefSeq (protein)

NP_055278

NP_080585

Location (UCSC)Chr 3: 14.18 – 14.2 MbChr 6: 91.52 – 91.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U6 snRNA-associated Sm-like protein LSm3 is a protein that in humans is encoded by the LSM3 gene.[5][6]

Function

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM][6]

Interactions

LSM3 has been shown to interact with LSM2[7][8][9][10] and LSM10.[7][9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170860 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034192 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (Jun 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". The EMBO Journal. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  6. 1 2 "Entrez Gene: LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  7. 1 2 Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  8. ↑ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  9. 1 2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  10. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

  • Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Lührmann R (Oct 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". The EMBO Journal. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  • Friesen WJ, Dreyfuss G (Aug 2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". The Journal of Biological Chemistry. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
  • Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and Rheumatism. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
  • Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". Rna. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (Dec 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". Rna. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
  • Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
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