LRCH4

LRCH4
Identifiers
AliasesLRCH4, LRN, LRRN1, LRRN4, PP14183, leucine-rich repeats and calponin homology (CH) domain containing 4, leucine rich repeats and calponin homology domain containing 4
External IDsMGI: 1917193 HomoloGene: 20532 GeneCards: LRCH4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q22.1Start100,574,011 bp[1]
End100,586,153 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4034

231798

Ensembl

ENSG00000077454

ENSMUSG00000093445

UniProt

O75427

Q921G6

RefSeq (mRNA)

NM_002319
NM_001289934

NM_001168652
NM_146164

RefSeq (protein)

NP_001276863
NP_002310

NP_001162123
NP_666276

Location (UCSC)Chr 7: 100.57 – 100.59 MbChr 5: 137.63 – 137.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine-rich repeat and calponin homology domain-containing protein 4 is a protein that in humans is encoded by the LRCH4 gene.[5][6]

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000077454 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093445 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). "Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes". Genome Res. 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793.
  6. 1 2 "Entrez Gene: LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Shiio Y, Rose DW, Aur R, et al. (2006). "Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex". Mol. Cell. Biol. 26 (4): 1386–97. doi:10.1128/MCB.26.4.1386-1397.2006. PMC 1367179. PMID 16449650.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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