LMOD3

LMOD3
Identifiers
AliasesLMOD3, NEM10, leiomodin 3
External IDsMGI: 2444169 HomoloGene: 28097 GeneCards: LMOD3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p14.1Start69,106,872 bp[1]
End69,123,032 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56203

320502

Ensembl

ENSG00000163380

ENSMUSG00000044086

UniProt

Q0VAK6

E9QA62

RefSeq (mRNA)

NM_198271
NM_001304418

NM_001081157

RefSeq (protein)

NP_001291347
NP_938012

NP_001074626

Location (UCSC)Chr 3: 69.11 – 69.12 MbChr 6: 97.24 – 97.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene.[5][6]

Clinical significance

Dysfunction is associated with thin filament disorganisation and nemaline myopathy.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163380 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044086 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: LMOD3 leiomodin 3 (fetal)".
  6. ↑ Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC (June 2015). "The evolution of compositionally and functionally distinct actin filaments". Journal of Cell Science. 128 (11): 2009–19. doi:10.1242/jcs.165563. PMID 25788699.
  7. ↑ Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, et al. (November 2014). "Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy". The Journal of Clinical Investigation. 124 (11): 4693–708. doi:10.1172/JCI75199. PMC 4347224. PMID 25250574.

Further reading

  • Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH (April 2006). "Risperidone-related weight gain: genetic and nongenetic predictors". Journal of Clinical Psychopharmacology. 26 (2): 128–34. doi:10.1097/01.jcp.0000203196.65710.2b. PMID 16633140.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


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