LIPH

LIPH
Identifiers
AliasesLIPH, AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1, lipase H
External IDsMGI: 2388029 HomoloGene: 71802 GeneCards: LIPH
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q27.2Start185,506,262 bp[1]
End185,552,613 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

200879

239759

Ensembl

ENSG00000163898

ENSMUSG00000044626

UniProt

Q8WWY8

Q8CIV3

RefSeq (mRNA)

NM_139248

NM_001083894
NM_001289581
NM_001289582
NM_153404

RefSeq (protein)

NP_640341

NP_001077363
NP_001276510
NP_001276511
NP_700453

Location (UCSC)Chr 3: 185.51 – 185.55 MbChr 16: 21.95 – 22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.[5][6][7]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163898 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044626 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Jin W, Broedl UC, Monajemi H, Glick JM, Rader DJ (Sep 2002). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine". Genomics. 80 (3): 268–73. doi:10.1006/geno.2002.6837. PMID 12213196.
  6. ↑ Sonoda H, Aoki J, Hiramatsu T, Ishida M, Bandoh K, Nagai Y, Taguchi R, Inoue K, Arai H (Sep 2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid". J Biol Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250.
  7. 1 2 "Entrez Gene: LIPH lipase, member H".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans". Hum. Mol. Genet. 12 (10): 1131–43. doi:10.1093/hmg/ddg124. PMID 12719377.
  • Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Aslam M, Chahrour MH, Razzaq A, et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33–q27.3". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMC 1735610. PMID 15520410.
  • Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH". Science. 314 (5801): 982–5. doi:10.1126/science.1133276. PMID 17095700.
  • Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis". Hum. Genet. 121 (3–4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281.


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